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Tbio
RNF168
E3 ubiquitin-protein ligase RNF168

Protein Summary
Description
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318037
  • ENSP00000320898
  • ENSG00000163961

Symbol
  • hRNF168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
transcription factor binding site profile
0.77
molecular function
0.76
transcription factor perturbation
0.68
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.5   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.5   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
36.7
mean corpuscular volume
1
1
1
5.9
mean reticulocyte volume
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
36.7
mean corpuscular volume
1
5.9
mean reticulocyte volume
1
4.8
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (147)
1 – 10 of 147
UBC
Tbio
Novelty: 0.00204643
Score: 0.997
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.997
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.995
Data Source: Reactome,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.995
Data Source: STRINGDB
RNF8
Tbio
Family: Enzyme
Novelty: 0.01189548
Score: 0.993
Data Source: Reactome,STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.991
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.989
Data Source: Reactome,STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.987
Data Source: Reactome,STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.982
Data Source: Reactome,STRINGDB
UIMC1
Tbio
Novelty: 0.02039732
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  54.50

PubMed score by year
PubTator Score  51.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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