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Tdark
CFAP46
Cilia- and flagella-associated protein 46

Protein Summary
Description
As part of the central apparatus of the cilium axoneme plays a role in cilium movement.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368585
  • ENSP00000357574
  • ENSG00000171811
  • ENST00000368586
  • ENSP00000357575

Symbol
  • C10orf123
  • C10orf124
  • C10orf92
  • C10orf93
  • TTC40
  • TTC40
  • C10orf92
  • C10orf93
  • C10orf123
  • C10orf124
  • bA288G11.4
  • bA288G11.5
  • bB137A17.2
  • bB137A17.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.64
tissue sample
0.55
cell line
0.54
tissue
0.52
histone modification site profile
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
21.5
Protein Structure (0 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
CFAP54
Tdark
Novelty:  0.91673101
Score:  0.813
Data Source:  STRINGDB
DNAH10
Tbio
Novelty:  0.17291083
Score:  0.775
Data Source:  STRINGDB
CFAP221
Tbio
Novelty:  0.14501712
Score:  0.758
Data Source:  STRINGDB
ERMARD
Tdark
Novelty:  0.3424066
Score:  0.747
Data Source:  STRINGDB
RNF115
Tbio
Family:  Enzyme
Novelty:  0.03523706
Score:  0.746
Data Source:  STRINGDB
PACRG
Tbio
Novelty:  0.01879528
Score:  0.732
Data Source:  STRINGDB
CXorf58
Tdark
Novelty:  1.57241379
Score:  0.707
Data Source:  STRINGDB
C19orf81
Tdark
Novelty:  12.43636364
Score:  0.701
Data Source:  STRINGDB
NPIPB11
Tdark
Novelty:  26
Score:  0.675
Data Source:  STRINGDB
DNAH2
Tbio
Novelty:  0.12847351
Score:  0.645
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.07

PubMed score by year
PubTator Score  1.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer