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Tbio
IZUMO1
Izumo sperm-egg fusion protein 1

Protein Summary
Description
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005). The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332955
  • ENSP00000327786
  • ENSG00000182264
  • ENST00000595517
  • ENSP00000471815
  • ENST00000595937
  • ENSP00000470144

Symbol
  • OBF
  • IZUMO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.81
tissue sample
0.74
transcription factor
0.61
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
p_int:  0.999994245
p_ni:  0.000005755
Data Source:  BioPlex
CRACR2A
Tchem
Novelty:  0.11259702
p_int:  0.999970795
p_ni:  0.000029205
Score:  0.188
Data Source:  BioPlex,STRINGDB
FAM84B
Tbio
Novelty:  0.10702561
p_int:  0.999645758
p_ni:  0.000131399
p_wrong:  0.000222842
Score:  0.187
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999516475
p_ni:  0.000483525
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.994130498
p_ni:  0.005869502
Data Source:  BioPlex
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.990440299
p_ni:  0.008407742
p_wrong:  0.001151959
Data Source:  BioPlex
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.981409471
p_ni:  0.015378008
p_wrong:  0.003212521
Data Source:  BioPlex
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.981080017
p_ni:  0.01859305
p_wrong:  0.000326932
Data Source:  BioPlex
LPGAT1
Tbio
Family:  Enzyme
Novelty:  0.06822609
p_int:  0.98024982
p_ni:  0.01975018
Score:  0.19
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.969653812
p_ni:  0.030342067
p_wrong:  0.000004121
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (R-HSA-1300645)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Reactome
Fertilization
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Fertilization
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (82)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
10
9
2.3
99.4
alkaline phosphatase measurement
4
6
5
16.2
99.4
low density lipoprotein cholesterol measurement
5
11
15
98.7
apolipoprotein B measurement
2
6
6
97.5
total cholesterol measurement
3
9
13
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
9
2.3
99.4
alkaline phosphatase measurement
5
16.2
99.4
low density lipoprotein cholesterol measurement
15
98.7
apolipoprotein B measurement
6
97.5
total cholesterol measurement
13
96.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
izumo sperm-egg fusion 1
VGNC:50527
107969781
Macaque
izumo sperm-egg fusion 1
718234
Mouse
MGI:1920706
73456
Rat
RGD:1565454
499152
Dog
izumo sperm-egg fusion 1
VGNC:42165
612013
Species
Name
OMA
EggNOG
Inparanoid
Chimp
izumo sperm-egg fusion 1
Macaque
izumo sperm-egg fusion 1
Mouse
Rat
Dog
izumo sperm-egg fusion 1
Publication Statistics
PubMed Score 71.88
PubMed score by year
PubTator Score 76.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title