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Tbio
HACE1
E3 ubiquitin-protein ligase HACE1

Protein Summary
Description
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262903
  • ENSP00000262903
  • ENSG00000085382
  • ENST00000369125
  • ENSP00000358121

Symbol
  • KIAA1320
  • SPPRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
kinase perturbation
0.81
histone modification site profile
0.8
microRNA
0.65
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (319)
1 – 10 of 319
UBA52
Tbio
Novelty:  0.01637744
Score:  0.973
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.973
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.972
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.949
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.948
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.945
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.941
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.941
Data Source:  STRINGDB
UBE2A
Tbio
Novelty:  0.01670792
Score:  0.939
Data Source:  STRINGDB
UBE2B
Tchem
Novelty:  0.01578275
Score:  0.939
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
6
5
6
3.8
98.8
body height
6
5
7
96.9
testosterone measurement
4
3
4
96
BMI-adjusted hip circumference
3
5
6
92.6
BMI-adjusted waist circumference
7
8
21
88.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
6
3.8
98.8
body height
7
96.9
testosterone measurement
4
96
BMI-adjusted hip circumference
6
92.6
BMI-adjusted waist circumference
21
88.7
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
VGNC:2855
462900
Macaque
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
696008
Mouse
MGI:2446110
209462
Rat
RGD:1306114
361866
Dog
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
VGNC:41583
475010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Macaque
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 11.85
PubMed score by year
PubTator Score 34.78
PubTator score by year