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Tchem
ULK2
Serine/threonine-protein kinase ULK2

Protein Summary
Description
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361658
  • ENSP00000354877
  • ENSG00000083290
  • ENST00000395544
  • ENSP00000378914

Symbol
  • KIAA0623
  • ATG1B
  • Unc51.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
protein domain
0.92
molecular function
0.91
small molecule
0.89
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.83   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.83   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
ATG101
Tbio
Novelty:  0.03407206
p_int:  0.946081167
p_ni:  2.2e-8
p_wrong:  0.053918811
Score:  0.99
Data Source:  BioPlex,STRINGDB
ATG13
Tbio
Novelty:  0.00951471
Score:  0.992
Data Source:  STRINGDB
RB1CC1
Tbio
Novelty:  0.00744817
Score:  0.991
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.988
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.968
Data Source:  STRINGDB
ATG14
Tbio
Novelty:  0.00914791
Score:  0.958
Data Source:  STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.951
Data Source:  STRINGDB
MLST8
Tbio
Novelty:  0.00423122
Score:  0.935
Data Source:  STRINGDB
ULK1
Tchem
Family:  Kinase
Novelty:  0.00240301
Score:  0.931
Data Source:  STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
Score:  0.93
Data Source:  STRINGDB
Pathways (6)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
mTOR signaling pathway
KEGG
Autophagy - animal
KEGG
Autophagy - other
Name
Explore in Pharos
Explore in Source
mTOR signaling pathway
Autophagy - animal
Autophagy - other
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
86.2
platelet count
3
3
2
2.1
83.5
intraocular pressure measurement
2
3
3
82
neutrophil count
2
2
2
57.1
creatinine measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.2
platelet count
2
2.1
83.5
intraocular pressure measurement
3
82
neutrophil count
2
57.1
creatinine measurement
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-51 like autophagy activating kinase 2
VGNC:9768
454507
Macaque
unc-51 like autophagy activating kinase 2
710708
Mouse
MGI:1352758
29869
Rat
RGD:1310181
303206
Dog
unc-51 like autophagy activating kinase 2
VGNC:48129
489525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-51 like autophagy activating kinase 2
Macaque
unc-51 like autophagy activating kinase 2
Mouse
Rat
Dog
unc-51 like autophagy activating kinase 2
Publication Statistics
PubMed Score 42.83
PubMed score by year
PubTator Score 19.23
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title