You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KATNAL2
Katanin p60 ATPase-containing subunit A-like 2

Protein Summary
Description
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245121
  • ENSP00000245121
  • ENSG00000167216
  • ENST00000356157
  • ENSP00000348478
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.8
protein domain
0.73
virus perturbation
0.72
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
KATNB1
Tbio
Novelty:  0.08472625
Score:  0.878
Data Source:  STRINGDB
STRIP1
Tbio
Novelty:  0.13320106
Score:  0.812
Data Source:  STRINGDB
POGZ
Tbio
Novelty:  0.03603188
Score:  0.793
Data Source:  STRINGDB
CHD8
Tbio
Family:  Epigenetic
Novelty:  0.01177693
Score:  0.725
Data Source:  STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
Score:  0.72
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.713
Data Source:  STRINGDB
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
Score:  0.677
Data Source:  STRINGDB
KATNBL1
Tdark
Novelty:  1.43589506
Score:  0.664
Data Source:  STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.654
Data Source:  STRINGDB
UTP15
Tbio
Novelty:  0.08174586
Score:  0.651
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
63.6
intelligence
1
1
1
51.7
1
1
1
51.7
biological sex
1
1
1
36.9
testosterone measurement
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
63.6
intelligence
1
51.7
1
51.7
biological sex
1
36.9
testosterone measurement
1
12.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
katanin catalytic subunit A1 like 2
VGNC:7317
455404
Macaque
katanin catalytic subunit A1 like 2
696856
Mouse
MGI:1924234
71206
Rat
RGD:1564708
307253
Dog
katanin catalytic subunit A1 like 2
VGNC:42218
490465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
katanin catalytic subunit A1 like 2
Macaque
katanin catalytic subunit A1 like 2
Mouse
Rat
Dog
katanin catalytic subunit A1 like 2
Publication Statistics
PubMed Score 8.39
PubMed score by year
PubTator Score 4.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title