OSCAR
Osteoclast-associated immunoglobulin-like receptor
Protein Summary
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
- ENST00000284648
- ENSP00000365808
- ENSG00000170909
- ENST00000391761
- ENSP00000375641
- ENST00000610577
- ENSP00000478594
- ENSG00000276982
- ENST00000610915
- ENSP00000479317
- ENSG00000277088
- ENST00000610985
- ENSP00000484755
- ENSG00000274703
- ENST00000611143
- ENSP00000477994
- ENSG00000278533
- ENST00000611480
- ENSP00000480193
- ENSG00000275551
- ENST00000611535
- ENSP00000483744
- ENSG00000275736
- ENST00000611715
- ENSP00000478382
- ENST00000611719
- ENSP00000478099
- ENSG00000275644
- ENST00000611918
- ENSP00000482460
- ENST00000611987
- ENSP00000478027
- ENST00000612289
- ENSP00000482414
- ENST00000612406
- ENSP00000478224
- ENSG00000273511
- ENST00000612953
- ENSP00000479954
- ENST00000613426
- ENSP00000480900
- ENST00000613814
- ENSP00000484125
- ENST00000614003
- ENSP00000481647
- ENST00000614380
- ENSP00000482734
- ENST00000615074
- ENSP00000477845
- ENST00000615546
- ENSP00000482402
- ENST00000616215
- ENSP00000479628
- ENST00000616227
- ENSP00000479849
- ENST00000616232
- ENSP00000484567
- ENST00000616461
- ENSP00000482610
- ENST00000616758
- ENSP00000481785
- ENST00000617187
- ENSP00000481805
- ENST00000617210
- ENSP00000482359
- ENSG00000278378
- ENST00000617622
- ENSP00000480863
- ENST00000617834
- ENSP00000481147
- ENST00000617993
- ENSP00000481261
- ENST00000618710
- ENSP00000484323
- ENST00000619170
- ENSP00000482545
- ENST00000619287
- ENSP00000484977
- ENST00000619631
- ENSP00000484878
- ENST00000620283
- ENSP00000483090
- ENST00000620647
- ENSP00000478216
- ENST00000621284
- ENSP00000477825
- ENST00000621290
- ENSP00000482791
- ENST00000621328
- ENSP00000482997
- ENST00000621506
- ENSP00000480424
- ENST00000621788
- ENSP00000481926
- ENST00000622288
- ENSP00000484602
- ENST00000622326
- ENSP00000481257
- PIGR3
- PIgR-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.64 | ||
tissue sample | 0.63 | ||
tissue | 0.59 | ||
histone modification site profile | 0.58 | ||
transcription factor | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.48 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.48 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0