You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TCEAL8
Transcription elongation factor A protein-like 8

Protein Classes
Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360000
  • ENSP00000353093
  • ENSG00000180964
  • ENST00000372685
  • ENSP00000361770

Symbol
  • WEX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
kinase perturbation
0.81
tissue sample
0.7
small molecule perturbation
0.63
cell type or tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
3.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913934
66684
Rat
RGD:1359631
367909
Dog
transcription elongation factor A like 8
100688714
Horse
transcription elongation factor A like 8
100059862
Cow
transcription elongation factor A like 8
VGNC:35683
768059
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transcription elongation factor A like 8
Horse
transcription elongation factor A like 8
Cow
transcription elongation factor A like 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IYN2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (20)
1 – 10 of 20
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.999921479
p_ni:  0.000009699
p_wrong:  0.000068822
Data Source:  BioPlex
TCEAL4
Tdark
Novelty:  1.13126125
Score:  0.748
Data Source:  STRINGDB
TCEAL5
Tdark
Novelty:  1.78893063
Score:  0.718
Data Source:  STRINGDB
TCEAL6
Tdark
Novelty:  0.88185411
Score:  0.703
Data Source:  STRINGDB
TCEAL3
Tdark
Novelty:  1.59394782
Score:  0.618
Data Source:  STRINGDB
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
Score:  0.594
Data Source:  STRINGDB
TCEAL2
Tdark
Novelty:  0.2679989
Score:  0.569
Data Source:  STRINGDB
BEX3
Tbio
Novelty:  0.02578005
Score:  0.567
Data Source:  STRINGDB
TMEM234
Tdark
Novelty:  1.24369839
Score:  0.509
Data Source:  STRINGDB
GPANK1
Tdark
Novelty:  0.20285376
Score:  0.504
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.82

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer