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Tbio
GPR65
Psychosine receptor

Protein Summary
Description
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267549
  • ENSP00000267549
  • ENSG00000140030

Symbol
  • TDAG8
  • TDAG8
  • hTDAG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
tissue sample
0.75
kinase perturbation
0.71
microRNA
0.71
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (201)
1 – 10 of 201
GPR132
Tchem
Family: GPCR
Novelty: 0.00189182
Score: 0.936
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.0018171
Score: 0.93
Data Source: STRINGDB
GNG10
Tdark
Novelty: 0.5797417
Score: 0.93
Data Source: STRINGDB
P2RY10
Tchem
Family: GPCR
Novelty: 0.30443923
Score: 0.928
Data Source: STRINGDB
FFAR4
Tchem
Family: GPCR
Novelty: 0.00603151
Score: 0.923
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00035891
Score: 0.923
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.04716243
Score: 0.921
Data Source: STRINGDB
XCR1
Tbio
Family: GPCR
Novelty: 0.01497998
Score: 0.921
Data Source: STRINGDB
XCL2
Tbio
Novelty: 0.072835
Score: 0.92
Data Source: STRINGDB
PTAFR
Tchem
Family: GPCR
Novelty: 0.00890235
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.75

PubMed score by year
PubTator Score  19.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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