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Tbio
GPR65
Psychosine receptor

Protein Summary
Description
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267549
  • ENSP00000267549
  • ENSG00000140030

Symbol
  • TDAG8
  • TDAG8
  • hTDAG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
tissue sample
0.75
kinase perturbation
0.71
microRNA
0.71
hub protein
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.48   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.48   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
GPR65-Tango
image for GPR65-Tango
Details:
  • Vector:  addgene66370
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR65-Tango
Order Genetic Construct from:
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
84.7
2
1
0
1.2
69.8
basophil percentage of leukocytes
1
1
1
67.4
basophil count
2
1
2
64
1
1
0
1.2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
84.7
0
1.2
69.8
basophil percentage of leukocytes
1
67.4
basophil count
2
64
0
1.2
61.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 65
693449
Mouse
MGI:108031
14744
Rat
RGD:1311832
299242
Dog
G protein-coupled receptor 65
VGNC:41442
490821
Horse
G protein-coupled receptor 65 [Source:HGNC Symbol;Acc:HGNC:4517]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 65
Mouse
Rat
Dog
G protein-coupled receptor 65
Horse
G protein-coupled receptor 65 [Source:HGNC Symbol;Acc:HGNC:4517]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IYL9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (201)
1 – 10 of 201
GPR132
Tchem
Family:  GPCR
Novelty:  0.00453902
Score:  0.936
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.93
Data Source:  STRINGDB
GNG10
Tdark
Novelty:  0.37659459
Score:  0.93
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.928
Data Source:  STRINGDB
FFAR4
Tchem
Family:  GPCR
Novelty:  0.00439747
Score:  0.923
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.923
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.921
Data Source:  STRINGDB
XCR1
Tbio
Family:  GPCR
Novelty:  0.00971657
Score:  0.921
Data Source:  STRINGDB
XCL2
Tbio
Novelty:  0.05252386
Score:  0.92
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  56.48

PubMed score by year
PubTator Score  19.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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