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Tbio
REM2
GTP-binding protein REM 2

Protein Summary
Description
Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267396
  • ENSP00000267396
  • ENSG00000139890
  • ENST00000536884
  • ENSP00000442774
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.73
tissue
0.53
tissue sample
0.53
cell line
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
3
4
86.7
heel bone mineral density
3
1
3
81.2
cup-to-disc ratio measurement
2
2
2
78.7
Dupuytren Contracture
1
1
0
1.3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.7
91
mathematical ability
4
86.7
heel bone mineral density
3
81.2
cup-to-disc ratio measurement
2
78.7
Dupuytren Contracture
0
1.3
71.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RRAD and GEM like GTPase 2
VGNC:10318
467399
Mouse
MGI:2155260
140743
Rat
RGD:69081
64626
Dog
RRAD and GEM like GTPase 2
VGNC:45473
490603
Horse
RRAD and GEM like GTPase 2
VGNC:51657
100146499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RRAD and GEM like GTPase 2
Mouse
Rat
Dog
RRAD and GEM like GTPase 2
Horse
RRAD and GEM like GTPase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IYK8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (12)
1 – 10 of 12
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.571
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.547
Data Source:  STRINGDB
CAV2
Tbio
Novelty:  0.00324146
Score:  0.545
Data Source:  STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.512
Data Source:  STRINGDB
RGL2
Tbio
Novelty:  0.04718269
Score:  0.499
Data Source:  STRINGDB
RAPGEFL1
Tdark
Novelty:  1.01382041
Score:  0.454
Data Source:  STRINGDB
RASGRP1
Tchem
Novelty:  0.00776879
Score:  0.441
Data Source:  STRINGDB
LRRK2
Tchem
Family:  Kinase
Novelty:  0.00068078
Score:  0.423
Data Source:  STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.418
Data Source:  STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.413
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.03

PubMed score by year
PubTator Score  42.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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