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Tbio
SYTL1
Synaptotagmin-like protein 1

Protein Summary
Description
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318074
  • ENSP00000316464
  • ENSG00000142765
  • ENST00000543823
  • ENSP00000440704
  • ENST00000616558
  • ENSP00000481032

Symbol
  • SLP1
  • JFC1
  • SLP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.92
cellular component
0.79
molecular function
0.7
transcription factor
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.36   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.36   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (48)
1 – 10 of 48
RAB27B
Tbio
Family:  Enzyme
Novelty:  0.01530218
p_int:  1
Score:  0.653
Data Source:  BioPlex,STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.999999993
p_ni:  6e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
TBC1D10A
Tbio
Novelty:  0.16930827
Score:  0.955
Data Source:  Reactome,STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.928
Data Source:  STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.922
Data Source:  STRINGDB
SYT13
Tbio
Novelty:  0.03332595
Score:  0.742
Data Source:  STRINGDB
MYRIP
Tbio
Novelty:  0.06456504
Score:  0.716
Data Source:  STRINGDB
SYT16
Tbio
Novelty:  0.05270686
Score:  0.714
Data Source:  STRINGDB
SYT14
Tbio
Novelty:  0.0413313
Score:  0.712
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.657
Data Source:  STRINGDB
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synaptotagmin like 1
715833
Mouse
MGI:1933365
269589
Rat
RGD:1310715
297872
Dog
synaptotagmin like 1
VGNC:53476
487346
Horse
synaptotagmin like 1
VGNC:23827
100070941
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synaptotagmin like 1
Mouse
Rat
Dog
synaptotagmin like 1
Horse
synaptotagmin like 1
Publication Statistics
PubMed Score 14.36
PubMed score by year
PubTator Score 19.70
PubTator score by year