Tbio EXOC8 Exocyst complex component 8

Protein Summary

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8IYI6
• B3KU33
• Q5TE82

Gene Name

• EXOC8

Ensembl ID

• ENST00000366645
• ENSP00000355605
• ENSG00000116903

Symbol

• EXO84
• SEC84
• Exo84p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
histone modification site profile	0.77
cell line	0.71
interacting protein	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.46   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.46   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0