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Tbio
EXOC8
Exocyst complex component 8

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366645
  • ENSP00000355605
  • ENSG00000116903

Symbol
  • EXO84
  • SEC84
  • Exo84p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.77
cell line
0.71
interacting protein
0.7
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
EXOC6
Tbio
Novelty:  0.01886811
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOC6B
Tbio
Novelty:  0.11301293
p_int:  0.999999922
p_ni:  7.7e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
SH3BP1
Tbio
Novelty:  8.50014339
p_int:  0.999998274
p_ni:  0.00000149
p_wrong:  2.36e-7
Score:  0.393
Data Source:  BioPlex,STRINGDB
EXOC7
Tbio
Novelty:  0.00852508
p_int:  0.999996301
p_ni:  0.000003699
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.999993332
p_ni:  0.000006668
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOC5
Tbio
Novelty:  0.02200205
p_int:  0.99998659
p_ni:  0.00001341
Score:  0.999
Data Source:  BioPlex,STRINGDB
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
p_int:  0.999970811
p_ni:  0.000029189
Score:  0.936
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999865553
p_ni:  0.000134447
Score:  0.997
Data Source:  BioPlex,STRINGDB
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999492797
p_ni:  0.000507048
p_wrong:  1.55e-7
Score:  0.801
Data Source:  BioPlex,STRINGDB
LRRC41
Tbio
Novelty:  0.12601472
p_int:  0.999209604
p_ni:  0.000790396
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (343)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
5
6
98
hemoglobin measurement
4
5
6
97.9
red blood cell density measurement
2
2
2
93.2
erythrocyte count
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
98
hemoglobin measurement
6
97.9
red blood cell density measurement
2
93.2
erythrocyte count
2
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
exocyst complex component 8
713483
Mouse
MGI:2142527
102058
Rat
RGD:620245
245709
Dog
exocyst complex component 8
VGNC:40519
488973
Horse
exocyst complex component 8
VGNC:17728
100051172
Species
Name
OMA
EggNOG
Inparanoid
Macaque
exocyst complex component 8
Mouse
Rat
Dog
exocyst complex component 8
Horse
exocyst complex component 8
Publication Statistics
PubMed Score 27.28
PubMed score by year
PubTator Score 8.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title