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Tdark
ZZZ3
ZZ-type zinc finger-containing protein 3

Protein Summary
Description
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
transcription factor binding site profile
0.91
histone modification site profile
0.82
virus perturbation
0.76
cell line
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger ZZ-type containing 3
VGNC:8147
456964
Mouse
MGI:1920453
108946
Dog
zinc finger ZZ-type containing 3
VGNC:48871
490203
Horse
zinc finger ZZ-type containing 3
VGNC:25432
100053222
Cow
zinc finger ZZ-type containing 3
VGNC:37397
538498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger ZZ-type containing 3
Mouse
Dog
zinc finger ZZ-type containing 3
Horse
zinc finger ZZ-type containing 3
Cow
zinc finger ZZ-type containing 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IYH5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Protein-Protein Interactions (70)
1 – 10 of 70
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.999999709
p_ni: 2.91e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
DR1
Tbio
Novelty: 0.00138571
p_int: 0.999999661
p_ni: 3.39e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.999998556
p_ni: 0.000001444
Score: 0.951
Data Source: BioPlex,STRINGDB
TADA3
Tbio
Novelty: 0.01743814
p_int: 0.999996761
p_ni: 0.000003239
Score: 0.982
Data Source: BioPlex,STRINGDB
IKZF5
Tbio
Family: TF
Novelty: 0.36596327
p_int: 0.99999572
p_ni: 0.00000428
Score: 0.23
Data Source: BioPlex,STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
p_int: 0.999834331
p_ni: 0.000165669
Score: 0.473
Data Source: BioPlex,STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999713587
p_ni: 0.000286413
Score: 0.968
Data Source: BioPlex,STRINGDB
PSME3
Tbio
Novelty: 0.01051254
p_int: 0.999654778
p_ni: 0.000345222
Score: 0.198
Data Source: BioPlex,STRINGDB
POLE4
Tdark
Family: Enzyme
Novelty: 0.23346084
p_int: 0.999310667
p_ni: 0.000689328
p_wrong: 5e-9
Score: 0.36
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999270706
p_ni: 0.000729294
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.82

PubMed score by year
PubTator Score  3.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer