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Tdark
ZZZ3
ZZ-type zinc finger-containing protein 3

Protein Summary
Description
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
transcription factor binding site profile
0.91
histone modification site profile
0.82
virus perturbation
0.76
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Protein-Protein Interactions (70)
1 – 10 of 70
MBIP
Tbio
Novelty: 0.10438201
p_int: 0.999999709
p_ni: 2.91e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
DR1
Tbio
Novelty: 0.00298399
p_int: 0.999999661
p_ni: 3.39e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
WDR5
Tchem
Novelty: 0.00689807
p_int: 0.999998556
p_ni: 0.000001444
Score: 0.951
Data Source: BioPlex,STRINGDB
TADA3
Tbio
Novelty: 0.02095177
p_int: 0.999996761
p_ni: 0.000003239
Score: 0.982
Data Source: BioPlex,STRINGDB
IKZF5
Tbio
Family: TF
Novelty: 1
p_int: 0.99999572
p_ni: 0.00000428
Score: 0.23
Data Source: BioPlex,STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.00962965
p_int: 0.999834331
p_ni: 0.000165669
Score: 0.473
Data Source: BioPlex,STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.00156606
p_int: 0.999713587
p_ni: 0.000286413
Score: 0.968
Data Source: BioPlex,STRINGDB
PSME3
Tbio
Novelty: 0.01291641
p_int: 0.999654778
p_ni: 0.000345222
Score: 0.198
Data Source: BioPlex,STRINGDB
POLE4
Tdark
Family: Enzyme
Novelty: 0.30757964
p_int: 0.999310667
p_ni: 0.000689328
p_wrong: 5e-9
Score: 0.36
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.0502828
p_int: 0.999270706
p_ni: 0.000729294
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.39

PubMed score by year
PubTator Score  3.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer