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Tdark
ELOA2
Elongin-A2

Protein Summary
Description
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332567
  • ENSP00000331302
  • ENSG00000206181

Symbol
  • TCEB3B
  • TCEB3L
  • HsT832
  • TCEB3B
  • TCEB3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
ANKS3
Tbio
Novelty:  0.19978252
p_int:  0.999999856
p_ni:  1.43e-7
p_wrong:  1e-9
Data Source:  BioPlex
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999996502
p_ni:  0.000003498
Data Source:  BioPlex
GIP
Tbio
Novelty:  0.0007219
p_int:  0.999490906
p_ni:  0.000509042
p_wrong:  5.2e-8
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.999308471
p_ni:  0.000690696
p_wrong:  8.33e-7
Data Source:  BioPlex
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.998634297
p_ni:  0.000931791
p_wrong:  0.000433912
Data Source:  BioPlex
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.994422233
p_ni:  0.005577694
p_wrong:  7.3e-8
Data Source:  BioPlex
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.991958628
p_ni:  0.008041372
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.98726386
p_ni:  0.01273614
Data Source:  BioPlex
ANKRD52
Tbio
Family:  Enzyme
Novelty:  0.14147652
p_int:  0.980331901
p_ni:  0.019663775
p_wrong:  0.000004325
Data Source:  BioPlex
ELOC
Tbio
Novelty:  0.00964847
p_int:  0.966450944
p_ni:  0.033549056
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
63.6
intelligence
1
1
1
51.7
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
63.6
intelligence
1
51.7
1
51.7
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.22
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title