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Tbio
FANCM
Fanconi anemia group M protein

Protein Summary
Description
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267430
  • ENSP00000267430
  • ENSG00000187790
  • ENST00000542564
  • ENSP00000442493
  • ENST00000556036
  • ENSP00000450596

Symbol
  • KIAA1596
  • POF15
  • SPGF28
  • FAAP250
  • KIAA1596
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.97
virus perturbation
0.95
transcription factor binding site profile
0.78
cell line
0.73


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.05   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.05   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group M
VGNC:3428
452885
Macaque
Fanconi anemia complementation group M
702513
Mouse
MGI:2442306
104806
Dog
FA complementation group M
VGNC:40725
480307
Horse
FA complementation group M
VGNC:17906
100063761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group M
Macaque
Fanconi anemia complementation group M
Mouse
Dog
FA complementation group M
Horse
FA complementation group M
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IYD8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (238)
1 – 10 of 238
FAAP24
Tbio
Novelty: 0.08081633
p_int: 0.999998066
p_ni: 0.00000191
p_wrong: 2.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
p_int: 0.993858826
p_ni: 0.006141174
Score: 0.934
Data Source: BioPlex,STRINGDB
MOCS2
Tbio
Family: Enzyme
Novelty: 0.04174383
p_int: 0.986589255
p_ni: 0.013383627
p_wrong: 0.000027118
Score: 0.685
Data Source: BioPlex,STRINGDB
PCLAF
Tbio
Novelty: 0.00328133
p_int: 0.970024997
p_ni: 0.029975003
Score: 0.893
Data Source: BioPlex,STRINGDB
FANCF
Tchem
Novelty: 0.01745498
Score: 0.999
Data Source: STRINGDB
FANCG
Tbio
Novelty: 0.00908902
Score: 0.999
Data Source: STRINGDB
CENPX
Tbio
Novelty: 0.08344454
Score: 0.999
Data Source: Reactome,STRINGDB
FANCL
Tbio
Family: Enzyme
Novelty: 0.00274467
Score: 0.999
Data Source: STRINGDB
CENPS
Tbio
Novelty: 0.0085893
Score: 0.999
Data Source: Reactome,STRINGDB
FANCA
Tbio
Novelty: 0.00324947
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  99.05

PubMed score by year
PubTator Score  55.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer