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Tbio
FANCM
Fanconi anemia group M protein

Protein Summary
Description
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267430
  • ENSP00000267430
  • ENSG00000187790
  • ENST00000542564
  • ENSP00000442493
  • ENST00000556036
  • ENSP00000450596

Symbol
  • KIAA1596
  • POF15
  • SPGF28
  • FAAP250
  • KIAA1596
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.97
virus perturbation
0.95
transcription factor binding site profile
0.78
cell line
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.45   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.45   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (238)
FAAP24
Tbio
Novelty:  0.08081633
p_int:  0.999998066
p_ni:  0.00000191
p_wrong:  2.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PCNA
Tchem
Novelty:  0.03909539
p_int:  0.993858826
p_ni:  0.006141174
Score:  0.934
Data Source:  BioPlex,STRINGDB
O96007
Tbio
Family:  Enzyme
Novelty:  0.04174383
p_int:  0.986589255
p_ni:  0.013383627
p_wrong:  0.000027118
Score:  0.685
Data Source:  BioPlex,STRINGDB
PCLAF
Tbio
Novelty:  0.00328133
p_int:  0.970024997
p_ni:  0.029975003
Score:  0.893
Data Source:  BioPlex,STRINGDB
FANCF
Tchem
Novelty:  0.01745498
Score:  0.999
Data Source:  STRINGDB
CENPX
Tbio
Novelty:  0.08344454
Score:  0.999
Data Source:  Reactome,STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
Score:  0.999
Data Source:  STRINGDB
FANCG
Tbio
Novelty:  0.00908902
Score:  0.999
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.999
Data Source:  Reactome,STRINGDB
FANCA
Tbio
Novelty:  0.00324947
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group M
VGNC:3428
452885
Macaque
Fanconi anemia complementation group M
702513
Mouse
MGI:2442306
104806
Dog
FA complementation group M
VGNC:40725
480307
Horse
FA complementation group M
VGNC:17906
100063761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group M
Macaque
Fanconi anemia complementation group M
Mouse
Dog
FA complementation group M
Horse
FA complementation group M
Publication Statistics
PubMed Score 103.45
PubMed score by year
PubTator Score 55.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title