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Tbio
SUPV3L1
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Protein Summary
Description
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359655
  • ENSP00000352678
  • ENSG00000156502

Symbol
  • SUV3
  • SUV3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
interacting protein
0.95
histone modification site profile
0.91
disease perturbation
0.9
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.52   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.52   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
14
14
99.7
lymphocyte count
3
3
3
88.3
aspartate aminotransferase measurement
2
2
1
7.7
86.4
birth weight
4
3
4
83.5
sex hormone-binding globulin measurement
3
2
3
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
14
99.7
lymphocyte count
3
88.3
aspartate aminotransferase measurement
1
7.7
86.4
birth weight
4
83.5
sex hormone-binding globulin measurement
3
78
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Suv3 like RNA helicase
VGNC:7263
466095
Mouse
MGI:2441711
338359
Rat
RGD:1305565
294385
Dog
Suv3 like RNA helicase
VGNC:46993
489018
Horse
Suv3 like RNA helicase
VGNC:23768
100072679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Suv3 like RNA helicase
Mouse
Rat
Dog
Suv3 like RNA helicase
Horse
Suv3 like RNA helicase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IYB8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.997625698
p_ni:  0.002374302
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.995188553
p_ni:  0.004811447
Score:  0.235
Data Source:  BioPlex,STRINGDB
HNRNPDL
Tbio
Novelty:  0.00222179
p_int:  0.992605418
p_ni:  0.007394582
Score:  0.194
Data Source:  BioPlex,STRINGDB
RBM3
Tbio
Novelty:  0.01066923
p_int:  0.992263846
p_ni:  0.007736154
Score:  0.19
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.990573321
p_ni:  0.00942667
p_wrong:  9e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
p_int:  0.988759077
p_ni:  0.007531329
p_wrong:  0.003709595
Score:  0.994
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.984030853
p_ni:  0.015965461
p_wrong:  0.000003686
Data Source:  BioPlex
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.977582909
p_ni:  0.022417091
Data Source:  BioPlex
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.97241333
p_ni:  0.027545459
p_wrong:  0.000041211
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.964968364
p_ni:  0.035027607
p_wrong:  0.000004028
Score:  0.464
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  70.52

PubMed score by year
PubTator Score  36.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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