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Tbio
SRRM1
Serine/arginine repetitive matrix protein 1

Protein Summary
Description
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323848
  • ENSP00000326261
  • ENSG00000133226

Symbol
  • SRM160
  • 160-KD
  • POP101
  • SRM160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
co-expressed gene
0.99
interacting protein
0.98
hub protein
0.94
transcription factor binding site profile
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
1
1
24.7
red blood cell density measurement
1
1
1
19.3
platelet crit
1
1
1
6.6
apolipoprotein A 1 measurement
1
1
1
4.1
platelet count
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
24.7
red blood cell density measurement
1
19.3
platelet crit
1
6.6
apolipoprotein A 1 measurement
1
4.1
platelet count
1
4.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine repetitive matrix 1
VGNC:8500
456632
Macaque
serine and arginine repetitive matrix 1
712258
Mouse
MGI:1858303
51796
Rat
RGD:1311258
313620
Horse
serine and arginine repetitive matrix 1
VGNC:23595
100071467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine repetitive matrix 1
Macaque
serine and arginine repetitive matrix 1
Mouse
Rat
Horse
serine and arginine repetitive matrix 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (340)
1 – 10 of 340
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.956044668
p_ni: 0.043955332
Data Source: BioPlex
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.91927326
p_ni: 0.08072674
Score: 0.608
Data Source: BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.906955756
p_ni: 0.093044244
Data Source: BioPlex
NIFK
Tbio
Novelty: 0.01221562
p_int: 0.892847455
p_ni: 0.107152544
Score: 0.161
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.874209379
p_ni: 0.125790621
Score: 0.205
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.83786229
p_ni: 0.16213771
Score: 0.312
Data Source: BioPlex,STRINGDB
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.832077375
p_ni: 0.167922625
Score: 0.639
Data Source: BioPlex,STRINGDB
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.831490602
p_ni: 0.168509398
Data Source: BioPlex
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.830510686
p_ni: 0.169489314
Data Source: BioPlex
RPL14
Tbio
Novelty: 0.01600377
p_int: 0.825184212
p_ni: 0.174815788
Score: 0.224
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.73

PubMed score by year
PubTator Score  16.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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