You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLX4
Structure-specific endonuclease subunit SLX4

Protein Summary
Description
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294008
  • ENSP00000294008
  • ENSG00000188827

Symbol
  • BTBD12
  • KIAA1784
  • KIAA1987
  • FANCP
  • BTBD12
  • MUS312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cell line
0.75
molecular function
0.73
cellular component
0.7
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.76   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.76   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
6
81.3
glomerular filtration rate
3
2
3
79.6
4
4
2
1
79.3
vital capacity
1
1
1
78.5
neutrophil count
3
1
3
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
81.3
glomerular filtration rate
3
79.6
2
1
79.3
vital capacity
1
78.5
neutrophil count
3
77.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLX4 structure-specific endonuclease subunit
VGNC:9394
453866
Mouse
MGI:106299
52864
Rat
RGD:1566009
302953
Dog
SLX4 structure-specific endonuclease subunit
VGNC:46517
479867
Horse
SLX4 structure-specific endonuclease subunit
VGNC:51243
100069533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLX4 structure-specific endonuclease subunit
Mouse
Rat
Dog
SLX4 structure-specific endonuclease subunit
Horse
SLX4 structure-specific endonuclease subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IY92-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Fanconi Anemia Pathway
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Protein-Protein Interactions (111)
1 – 10 of 111
ERCC1
Tbio
Novelty:  0.00079472
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.999276664
p_ni:  0.000022635
p_wrong:  0.000700701
Score:  0.165
Data Source:  BioPlex,STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
p_int:  0.99812789
p_ni:  0.001797017
p_wrong:  0.000075093
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SLX1A
Tbio
Family:  Enzyme
Novelty:  0.0310173
Score:  0.998
Data Source:  Reactome,STRINGDB
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
Score:  0.993
Data Source:  Reactome,STRINGDB
FANCD2
Tbio
Novelty:  0.00316101
Score:  0.991
Data Source:  STRINGDB
ERCC4
Tbio
Family:  Enzyme
Novelty:  0.01076913
Score:  0.987
Data Source:  STRINGDB
FANCI
Tbio
Novelty:  0.01223788
Score:  0.986
Data Source:  STRINGDB
DCLRE1B
Tbio
Family:  Enzyme
Novelty:  0.0598925
Score:  0.983
Data Source:  STRINGDB
FANCA
Tbio
Novelty:  0.00324947
Score:  0.982
Data Source:  STRINGDB
Publication Statistics
PubMed Score  75.76

PubMed score by year
PubTator Score  47.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: