Tbio FTSJ3 pre-rRNA processing protein FTSJ3

Protein Summary

Description

Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IY81
• B2RCA5
• D3DU22
• Q8N3A3
• Q8WXX1
• Q9BWM4
• Q9NXT6

Gene Name

• FTSJ3

Ensembl ID

• ENST00000427159
• ENSP00000396673
• ENSG00000108592

Symbol

• SPB1
• EPCS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
kinase perturbation	0.95
transcription factor binding site profile	0.88
drug perturbation	0.87
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.89   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.89   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0