Tbio RAVER1 Ribonucleoprotein PTB-binding 1

Protein Summary

Description

Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Uniprot Accession IDs

• Q8IY67
• A6NMU4
• Q8IY60
• Q8TF24

Gene Name

• RAVER1

Ensembl ID

• ENST00000615032
• ENSP00000479520
• ENSG00000161847

Symbol

• KIAA1978

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.96
ligand (protein) perturbation	0.96
histone modification site profile	0.89
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Ribonucleoprotein Ptb-binding 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Ribonucleoprotein Ptb-binding 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0