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Tbio
YAF2
YY1-associated factor 2

Protein Summary
Description
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327791
  • ENSP00000328004
  • ENSG00000015153
  • ENST00000380790
  • ENSP00000370167
  • ENST00000534854
  • ENSP00000439256
  • ENST00000555248
  • ENSP00000451626
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
microRNA
0.75
transcription factor binding site profile
0.75
histone modification site profile
0.7
PubMedID
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
21.5
diastolic blood pressure
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
21.5
diastolic blood pressure
1
9.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
YY1 associated factor 2
699068
Mouse
MGI:1914307
67057
Rat
RGD:1582851
690262
Dog
YY1 associated factor 2
VGNC:49709
609790
Horse
YY1 associated factor 2
VGNC:25091
100054055
Species
Name
OMA
EggNOG
Inparanoid
Macaque
YY1 associated factor 2
Mouse
Rat
Dog
YY1 associated factor 2
Horse
YY1 associated factor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IY57-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome
Transcriptional Regulation by E2F6
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6
Protein-Protein Interactions (81)
1 – 10 of 81
PCGF2
Tbio
Novelty:  0.02148755
p_int:  1
Score:  0.857
Data Source:  BioPlex,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999999999
p_ni:  1e-9
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
PCGF1
Tbio
Novelty:  0.06481661
p_int:  0.999999673
p_ni:  3.26e-7
p_wrong:  2e-9
Score:  0.835
Data Source:  BioPlex,STRINGDB
PCGF3
Tbio
Novelty:  0.14226976
p_int:  0.999999472
p_ni:  4.86e-7
p_wrong:  4.2e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
KDM2B
Tchem
Family:  Epigenetic
Novelty:  0.01630517
p_int:  0.999999362
p_ni:  6.37e-7
p_wrong:  1e-9
Score:  0.933
Data Source:  BioPlex,STRINGDB
BMI1
Tbio
Novelty:  0.00158043
p_int:  0.999998607
p_ni:  0.000001393
Score:  0.725
Data Source:  BioPlex,STRINGDB
FBRS
Tbio
Novelty:  0.13646817
p_int:  0.999998251
p_ni:  0.000001749
Score:  0.725
Data Source:  BioPlex,STRINGDB
AGGF1
Tbio
Novelty:  0.02757407
p_int:  0.999996108
p_ni:  0.000003891
Data Source:  BioPlex
PCGF5
Tdark
Novelty:  0.11370936
p_int:  0.999994695
p_ni:  3.76e-7
p_wrong:  0.000004929
Score:  0.994
Data Source:  BioPlex,STRINGDB
MORC4
Tbio
Novelty:  0.17017364
p_int:  0.99998818
p_ni:  0.000011568
p_wrong:  2.52e-7
Score:  0.664
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.11

PubMed score by year
PubTator Score  3.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer