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Tdark
DHX37
Probable ATP-dependent RNA helicase DHX37

Protein Summary
Description
This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308736
  • ENSP00000311135
  • ENSG00000150990

Symbol
  • DDX37
  • KIAA1517
  • Dhr1
  • DDX37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
kinase perturbation
0.81
cell line
0.65
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.96   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.96   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (316)
UTP14A
Tbio
Novelty:  0.06076507
p_int:  0.975351784
p_ni:  0.024648216
Score:  0.998
Data Source:  BioPlex,STRINGDB
GNL3
Tbio
Novelty:  0.00886703
p_int:  0.839049042
p_ni:  0.160950958
Score:  0.789
Data Source:  BioPlex,STRINGDB
RSBN1
Tbio
Novelty:  0.1955858
p_int:  0.802773733
p_ni:  0.197226267
Score:  0.237
Data Source:  BioPlex,STRINGDB
NOL6
Tbio
Novelty:  0.10002413
Score:  0.997
Data Source:  STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.997
Data Source:  STRINGDB
NOC4L
Tdark
Novelty:  0.39929311
Score:  0.997
Data Source:  STRINGDB
MPHOSPH10
Tbio
Novelty:  0.04846226
Score:  0.997
Data Source:  STRINGDB
UTP4
Tbio
Novelty:  0.06989008
Score:  0.997
Data Source:  STRINGDB
UTP3
Tbio
Novelty:  0.06371711
Score:  0.996
Data Source:  STRINGDB
UTP14C
Tdark
Novelty:  0.22698737
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
7
15
97.8
apolipoprotein A 1 measurement
2
3
3
93.3
sleep duration
2
3
3
83.5
total cholesterol measurement
2
2
2
69.1
hip circumference
1
2
2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
15
97.8
apolipoprotein A 1 measurement
3
93.3
sleep duration
3
83.5
total cholesterol measurement
2
69.1
hip circumference
2
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DEAH-box helicase 37
706709
Mouse
MGI:3028576
208144
Rat
RGD:1306837
288647
Dog
DEAH-box helicase 37
VGNC:39947
477442
Horse
DEAH-box helicase 37
VGNC:17178
100059323
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DEAH-box helicase 37
Mouse
Rat
Dog
DEAH-box helicase 37
Horse
DEAH-box helicase 37
Publication Statistics
PubMed Score 40.96
PubMed score by year
PubTator Score 0.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title