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Tbio
IFT20
Intraflagellar transport protein 20 homolog

Protein Summary
Description
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). This gene encodes a intraflagellar transport protein important for intracell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357896
  • ENSP00000350570
  • ENSG00000109083
  • ENST00000395418
  • ENSP00000378809
  • ENST00000579419
  • ENSP00000463322
  • ENST00000585089
  • ENSP00000464443
  • ENST00000585313
  • ENSP00000463138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.89
transcription factor binding site profile
0.89
transcription factor
0.79
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.99999975
p_ni:  2.4e-7
p_wrong:  1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
DEUP1
Tbio
Novelty:  0.13274391
p_int:  0.999999013
p_ni:  9.7e-7
p_wrong:  1.7e-8
Score:  0.227
Data Source:  BioPlex,STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.999995999
p_ni:  0.000004001
Data Source:  BioPlex
SAPCD2
Tbio
Novelty:  0.06798955
p_int:  0.999995783
p_ni:  0.000004217
Data Source:  BioPlex
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.999991849
p_ni:  0.000007315
p_wrong:  8.36e-7
Data Source:  BioPlex
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999968642
p_ni:  0.000031358
Score:  0.974
Data Source:  BioPlex,STRINGDB
TARBP1
Tbio
Family:  Enzyme
Novelty:  0.04886897
p_int:  0.999957505
p_ni:  0.000042493
p_wrong:  2e-9
Data Source:  BioPlex
TKFC
Tbio
Family:  Enzyme
Novelty:  0.00380602
p_int:  0.999949052
p_ni:  0.000050945
p_wrong:  3e-9
Data Source:  BioPlex
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999937849
p_ni:  0.000058415
p_wrong:  0.000003736
Score:  0.988
Data Source:  BioPlex,STRINGDB
COL4A3BP
Tbio
Novelty:  0.00357203
p_int:  0.99991302
p_ni:  0.00008698
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 20
VGNC:9331
468195
Macaque
intraflagellar transport 20
715773
Mouse
MGI:1915585
55978
Rat
RGD:1309400
287541
Dog
intraflagellar transport 20
480620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 20
Macaque
intraflagellar transport 20
Mouse
Rat
Dog
intraflagellar transport 20
Publication Statistics
PubMed Score 43.31
PubMed score by year
PubTator Score 16.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title