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Tbio
PLPP6
Phospholipid phosphatase 6

Protein Summary
Description
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381883
  • ENSP00000371307
  • ENSG00000205808

Symbol
  • PPAPDC2
  • PDP1
  • PSDP
  • PPAPDC2
  • bA6J24.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921661
74411
Rat
RGD:1566000
619549
Dog
phospholipid phosphatase 6
VGNC:44709
609595
Cow
phospholipid phosphatase 6
VGNC:33049
541021
Pig
phospholipid phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:23682]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipid phosphatase 6
Cow
phospholipid phosphatase 6
Pig
phospholipid phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:23682]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IY26-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (34)
1 – 10 of 34
MSMP
Tdark
Novelty: 0.06380006
Score: 0.93
Data Source: STRINGDB
PLPP1
Tbio
Family: Enzyme
Novelty: 0.06521084
Score: 0.892
Data Source: STRINGDB
PRRC2C
Tbio
Novelty: 0.25128003
Score: 0.725
Data Source: STRINGDB
PIGC
Tbio
Family: Enzyme
Novelty: 0.02057578
Score: 0.71
Data Source: STRINGDB
SUCO
Tdark
Novelty: 0.00074481
Score: 0.71
Data Source: STRINGDB
METTL13
Tbio
Family: Enzyme
Novelty: 0.15986409
Score: 0.705
Data Source: STRINGDB
VAMP4
Tbio
Novelty: 0.02949854
Score: 0.657
Data Source: STRINGDB
INPP5J
Tbio
Family: Enzyme
Novelty: 0.0537284
Score: 0.642
Data Source: STRINGDB
ATRAID
Tbio
Novelty: 0.05036748
Score: 0.586
Data Source: STRINGDB
TM9SF4
Tbio
Novelty: 0.10441964
Score: 0.583
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.73

PubMed score by year
PubTator Score  13.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer