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Tbio
PNPLA6
Neuropathy target esterase

Protein Summary
Description
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221249
  • ENSP00000221249
  • ENSG00000032444
  • ENST00000414982
  • ENSP00000407509
  • ENST00000450331
  • ENSP00000394348
  • ENST00000545201
  • ENSP00000443323

Symbol
  • NTE
  • NTE
  • sws
  • BNHS
  • LNMS
  • OMCS
  • SPG39
  • NTEMND
  • iPLA2delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
protein domain
0.85
transcription factor
0.8
metabolite
0.78
interacting protein
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.4   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.4   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 6
VGNC:6648
455659
Macaque
patatin like phospholipase domain containing 6
100426338
Mouse
MGI:1354723
50767
Rat
RGD:1564611
360753
Dog
patatin like phospholipase domain containing 6
VGNC:44756
484993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 6
Macaque
patatin like phospholipase domain containing 6
Mouse
Rat
Dog
patatin like phospholipase domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IY17-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (132)
1 – 10 of 132
IFNLR1
Tbio
Novelty: 0.01990628
p_int: 0.980946792
p_ni: 0.019053208
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00042077
p_int: 0.973474803
p_ni: 0.026525197
Data Source: BioPlex
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.965651363
p_ni: 0.034348637
Data Source: BioPlex
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.963658886
p_ni: 0.036341114
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.958018845
p_ni: 0.041981155
Data Source: BioPlex
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.919451525
p_ni: 0.080548475
Data Source: BioPlex
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.907507894
p_ni: 0.092492106
Data Source: BioPlex
STIM1
Tbio
Novelty: 0.00116516
p_int: 0.892541484
p_ni: 0.107458516
Data Source: BioPlex
PCDHGC5
Tdark
Novelty: 0.39651826
p_int: 0.885063203
p_ni: 0.114936797
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.876959444
p_ni: 0.123040546
p_wrong: 1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  338.40

PubMed score by year
PubTator Score  299.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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