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Tdark
PPIL6
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6

Protein Summary
Description
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424445
  • ENSP00000407731
  • ENSG00000185250
  • ENST00000440797
  • ENSP00000392257
  • ENST00000521072
  • ENSP00000427929

Symbol
  • PPIase
  • RSPH12
  • bA425D10.6
  • dJ919F19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
tissue sample
0.65
microRNA
0.61
transcription factor binding site profile
0.52
cellular component
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (219)
CDC40
Tbio
Novelty:  0.03139044
Score:  0.939
Data Source:  STRINGDB
HNRNPD
Tbio
Novelty:  0.00538829
Score:  0.937
Data Source:  STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.937
Data Source:  STRINGDB
CWC15
Tbio
Novelty:  0.00205068
Score:  0.936
Data Source:  STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.936
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.936
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.935
Data Source:  STRINGDB
BUD31
Tbio
Novelty:  0.13364384
Score:  0.935
Data Source:  STRINGDB
LSM8
Tbio
Novelty:  0.08782322
Score:  0.934
Data Source:  STRINGDB
PRPF38A
Tbio
Novelty:  0.10698531
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
3
3
98.1
basophil count
4
4
4
92.9
mean corpuscular volume
5
5
5
92.2
mean corpuscular hemoglobin
3
3
3
90.9
mosaic loss of chromosome Y measurement
3
2
3
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
98.1
basophil count
4
92.9
mean corpuscular volume
5
92.2
mean corpuscular hemoglobin
3
90.9
mosaic loss of chromosome Y measurement
3
90.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 6
VGNC:3666
740130
Macaque
peptidylprolyl isomerase like 6
698986
Mouse
MGI:1920325
73075
Rat
RGD:1592581
685567
Dog
peptidylprolyl isomerase like 6
VGNC:44858
612243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 6
Macaque
peptidylprolyl isomerase like 6
Mouse
Rat
Dog
peptidylprolyl isomerase like 6
Publication Statistics
PubMed Score 0.56
PubMed score by year
PubTator Score 1.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title