Tbio RPAP2 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Protein Summary

Description

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

Uniprot Accession IDs

• Q8IXW5
• C9JKB5
• Q49AS7
• Q9H8Y2

Gene Name

• RPAP2

Ensembl ID

• ENST00000610020
• ENSP00000476948
• ENSG00000122484

Symbol

• C1orf82
• Rtr1
• C1orf82

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.88
transcription factor perturbation	0.8
cellular component	0.69
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0