Tbio RPAP2 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Protein Summary

Description

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

Uniprot Accession IDs

• Q8IXW5
• C9JKB5
• Q49AS7
• Q9H8Y2

Gene Name

• RPAP2

Ensembl ID

• ENST00000610020
• ENSP00000476948
• ENSG00000122484

Symbol

• C1orf82
• Rtr1
• C1orf82

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.88
transcription factor perturbation	0.8
cellular component	0.69
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (151)

Explore Interacting Targets

1 – 10 of 151

• See Interactions on String-DB

LMO2

Tbio

Novelty:  0.0038279

p_int:  0.999994677

p_ni:  0.000005323

Score:  0.519

Data Source:  BioPlex,STRINGDB

POLR2J

Tbio

Family:  Enzyme

Novelty:  0.02344868

p_int:  0.999993187

p_ni:  0.000006813

Score:  0.987

Data Source:  BioPlex,STRINGDB

POLR2G

Tbio

Family:  Enzyme

Novelty:  0.01235379

p_int:  0.999990731

p_ni:  0.000009269

Score:  0.994

Data Source:  BioPlex,STRINGDB

GPN3

Tbio

Family:  Enzyme

Novelty:  0.13817794

p_int:  0.999983337

p_ni:  0.000016663

Score:  0.947

Data Source:  BioPlex,STRINGDB

PIH1D1

Tbio

Novelty:  0.10737369

p_int:  0.999945259

p_ni:  0.000054741

Score:  0.881

Data Source:  BioPlex,STRINGDB

RPRD1B

Tbio

Novelty:  0.0444394

p_int:  0.99990413

p_ni:  0.00009587

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

GPN1

Tbio

Family:  Enzyme

Novelty:  0.06883613

p_int:  0.999889175

p_ni:  0.000110825

Score:  0.941

Data Source:  BioPlex,STRINGDB

Q6EEV4

Tbio

Family:  Enzyme

Novelty:  0.11413088

p_int:  0.999850099

p_ni:  0.000149901

Score:  0.809

Data Source:  BioPlex,STRINGDB

POLR2D

Tdark

Family:  Enzyme

Novelty:  0.11021614

p_int:  0.999765861

p_ni:  0.000234139

Score:  0.991

Data Source:  BioPlex,STRINGDB

ASB6

Tdark

Novelty:  0.32074223

p_int:  0.999469498

p_ni:  0.000530502

Score:  0.632

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA polymerase II transcribes snRNA genes	71 targets	R-HSA-6807505

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA polymerase II transcribes snRNA genes	71 targets	R-HSA-6807505

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (4)

Components (6)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein serine/threonine phosphatase activity	Inferred from Experiment (EXP)	Reactome
RNA polymerase II CTD heptapeptide repeat phosphatase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
RNA polymerase core enzyme binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	4	4		98.1
monocyte count	EFO_0005091	1	2	2		95.7
granulocyte percentage of myeloid white cells	EFO_0007997	1	2	2		95
lymphocyte percentage of leukocytes	EFO_0007993	2	2	2		83.1
myeloid white cell count	EFO_0007988	2	2	2		81.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	4		98.1
monocyte count	EFO_0005091	2		95.7
granulocyte percentage of myeloid white cells	EFO_0007997	2		95
lymphocyte percentage of leukocytes	EFO_0007993	2		83.1
myeloid white cell count	EFO_0007988	2		81.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Protein phosphatase

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
granulocyte percentage of myeloid white cells
leukocyte count
lymphocyte count
lymphocyte percentage of leukocytes
monocyte count
monocyte percentage of leukocytes
multiple sclerosis
myeloid white cell count
neutrophil percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	RNA polymerase II associated protein 2		706358
Mouse	RNA polymerase II associated protein 2	MGI:2141142	231571
Rat	RNA polymerase II associated protein 2	RGD:1309034	305120
Horse	RNA polymerase II associated protein 2	VGNC:22513	100059972
Cow	RNA polymerase II associated protein 2	VGNC:34099	529184

Species	Name	OMA	EggNOG	Inparanoid
Macaque	RNA polymerase II associated protein 2
Mouse	RNA polymerase II associated protein 2
Rat	RNA polymerase II associated protein 2
Horse	RNA polymerase II associated protein 2
Cow	RNA polymerase II associated protein 2

Publication Statistics

PubMed Score 33.81

PubMed score by year

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PubTator Score 10.63

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (3)

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PMID	Year	Title