Tbio ETFBKMT Electron transfer flavoprotein beta subunit lysine methyltransferase

Protein Summary

Description

Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781).

Uniprot Accession IDs

• Q8IXQ9
• D3DUW3

Gene Name

• ETFBKMT

Ensembl ID

• ENST00000357721
• ENSP00000350353
• ENSG00000139160
• ENST00000395763
• ENSP00000379112
• ENST00000412352
• ENSP00000396123
• ENST00000538463
• ENSP00000441421

Symbol

• C12orf72
• METTL20
• METTL20
• C12orf72
• ETFB-KMT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rna Methyltransferase / Electron Transfer Flavoprotein Beta Subunit Lysine Methyltransferase

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Electron Transfer Flavoprotein Beta Subunit Lysine Methyltransferase

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Methyltransferase / Electron Transfer Flavoprotein Beta Subunit Lysine Methyltransferase

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Electron Transfer Flavoprotein Beta Subunit Lysine Methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.04   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0