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Tdark
RIMKLA
N-acetylaspartylglutamate synthase A

Protein Summary
Description
Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431473
  • ENSP00000414330
  • ENSG00000177181

Symbol
  • FAM80A
  • NAAGS
  • FAM80A
  • NAAGS-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
histone modification site profile
0.76
microRNA
0.71
tissue sample
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal modification protein rimK like family member A
VGNC:11886
748944
Macaque
ribosomal modification protein rimK like family member A
699767
Mouse
MGI:3040686
194237
Rat
Dog
ribosomal modification protein rimK like family member A
VGNC:45580
482445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal modification protein rimK like family member A
Macaque
ribosomal modification protein rimK like family member A
Mouse
Rat
Dog
ribosomal modification protein rimK like family member A
Pathways (5)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
CBWD3
Tdark
Novelty: 0.03639787
p_int: 0.997960439
p_ni: 0.002039554
p_wrong: 8e-9
Score: 0.226
Data Source: BioPlex,STRINGDB
DHTKD1
Tbio
Family: Enzyme
Novelty: 0.0381406
p_int: 0.996253657
p_ni: 0.003746045
p_wrong: 2.98e-7
Score: 0.564
Data Source: BioPlex,STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
p_int: 0.894559256
p_ni: 0.080328251
p_wrong: 0.025112493
Score: 0.335
Data Source: BioPlex,STRINGDB
NAT8L
Tbio
Family: Enzyme
Novelty: 0.01761988
Score: 0.972
Data Source: STRINGDB
FOLH1
Tchem
Family: Enzyme
Novelty: 0.0002861
Score: 0.955
Data Source: STRINGDB
ASPA
Tbio
Family: Enzyme
Novelty: 0.02701619
Score: 0.925
Data Source: STRINGDB
RIMKLB
Tbio
Family: Enzyme
Novelty: 0.17814588
Score: 0.905
Data Source: STRINGDB
MCCD1
Tdark
Novelty: 0.55621159
Score: 0.742
Data Source: STRINGDB
FBLL1
Tdark
Family: Enzyme
Novelty: 1.53294318
Score: 0.718
Data Source: STRINGDB
MSMB
Tbio
Novelty: 0.00241546
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.08

PubMed score by year
PubTator Score  1.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer