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Tbio
MRPL41
39S ribosomal protein L41, mitochondrial

Protein Summary
Description
Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371443
  • ENSP00000360498
  • ENSG00000182154

Symbol
  • BMRP
  • MRPL27
  • RPML27
  • BMRP
  • PIG3
  • MRPL27
  • RPML27
  • MRP-L27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
small molecule perturbation
0.82
interacting protein
0.8
histone modification site profile
0.69
disease perturbation
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L41
VGNC:4789
737212
Rat
RGD:1560917
501028
Dog
mitochondrial ribosomal protein L41
VGNC:43398
491225
Cow
mitochondrial ribosomal protein L41
VGNC:31637
506521
Opossum
mitochondrial ribosomal protein L41
100018635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L41
Rat
Dog
mitochondrial ribosomal protein L41
Cow
mitochondrial ribosomal protein L41
Opossum
mitochondrial ribosomal protein L41
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IXM3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (143)
1 – 10 of 143
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.99999621
p_ni: 0.00000379
Score: 0.998
Data Source: BioPlex,STRINGDB
PREPL
Tchem
Family: Enzyme
Novelty: 0.02310586
p_int: 0.999957214
p_ni: 0.000042786
Data Source: BioPlex
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999832301
p_ni: 0.000167699
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.998345163
p_ni: 0.001654837
Score: 0.997
Data Source: BioPlex,STRINGDB
NBR1
Tbio
Novelty: 0.00893066
p_int: 0.998097447
p_ni: 0.001901393
p_wrong: 0.000001161
Data Source: BioPlex
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.998077412
p_ni: 0.001922588
Score: 0.997
Data Source: BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
p_int: 0.997822502
p_ni: 0.002177498
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL27
Tbio
Novelty: 0.15636105
p_int: 0.997667116
p_ni: 0.002332884
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL32
Tdark
Novelty: 0.58976136
p_int: 0.997561101
p_ni: 0.002438896
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
p_int: 0.995951917
p_ni: 0.004048083
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.44

PubMed score by year
PubTator Score  5.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer