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Tbio
MSRB3
Methionine-R-sulfoxide reductase B3

Protein Summary
Description
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308259
  • ENSP00000312274
  • ENSG00000174099
  • ENST00000355192
  • ENSP00000347324
  • ENST00000535664
  • ENSP00000441650
  • ENST00000614640
  • ENSP00000481483
  • ENST00000642404
  • ENSP00000496008
  • ENST00000642411
  • ENSP00000494265
  • ENST00000646299
  • ENSP00000494941

Symbol
  • DFNB74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.94
kinase perturbation
0.93
histone modification site profile
0.83
microRNA
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.08   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.08   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
4
3
0
33.5
88.6
heel bone mineral density
3
3
5
85.9
1
1
1
80.6
hippocampal CA1 volume
2
1
0
14
78.5
cortical surface area measurement
1
1
0
32.2
76.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
0
33.5
88.6
heel bone mineral density
5
85.9
1
80.6
hippocampal CA1 volume
0
14
78.5
cortical surface area measurement
0
32.2
76.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase B3
VGNC:13422
744605
Macaque
methionine sulfoxide reductase B3
717617
Mouse
MGI:2443538
320183
Rat
RGD:1596851
680036
Dog
methionine sulfoxide reductase B3
VGNC:43451
608386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase B3
Macaque
methionine sulfoxide reductase B3
Mouse
Rat
Dog
methionine sulfoxide reductase B3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IXL7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Protein repair
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Protein repair
Protein-Protein Interactions (49)
1 – 10 of 49
KLHL7
Tbio
Novelty:  0.0522116
p_int:  0.999999977
p_ni:  2.2e-8
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
RBP4
Tchem
Novelty:  0.00168442
p_int:  0.999988428
p_ni:  0.000010758
p_wrong:  8.13e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
SPOP
Tbio
Novelty:  0.00663363
p_int:  0.998987629
p_ni:  0.000342217
p_wrong:  0.000670154
Score:  0.243
Data Source:  BioPlex,STRINGDB
DCUN1D4
Tchem
Novelty:  1.30623399
p_int:  0.998325593
p_ni:  0.001674407
Score:  0.252
Data Source:  BioPlex,STRINGDB
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.966758034
p_ni:  0.032652107
p_wrong:  0.000589859
Score:  0.169
Data Source:  BioPlex,STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.964570214
p_ni:  0.035429786
Score:  0.163
Data Source:  BioPlex,STRINGDB
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.882932693
p_ni:  0.117067299
p_wrong:  8e-9
Data Source:  BioPlex
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.819673072
p_ni:  0.180326928
Data Source:  BioPlex
MSRA
Tbio
Family:  Enzyme
Novelty:  0.00595154
Score:  0.991
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.946
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  39.08

PubMed score by year
PubTator Score  15.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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