Tbio GALNT12 Polypeptide N-acetylgalactosaminyltransferase 12

Protein Summary

Description

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q8IXK2
• Q5TCF7
• Q8NG54
• Q96CT9
• Q9H771

Gene Name

• GALNT12

Ensembl ID

• ENST00000375011
• ENSP00000364150
• ENSG00000119514

Symbol

• CRCS1
• GalNAc-T12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.87
PubMedID	0.75
histone modification site profile	0.73
transcription factor perturbation	0.68
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Polypeptide N-acetylgalactosaminyltransferase 12

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Polypeptide N-acetylgalactosaminyltransferase 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0