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Tbio
GALNT12
Polypeptide N-acetylgalactosaminyltransferase 12

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375011
  • ENSP00000364150
  • ENSG00000119514

Symbol
  • CRCS1
  • GalNAc-T12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
PubMedID
0.75
histone modification site profile
0.73
transcription factor perturbation
0.68
tissue sample
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 12
VGNC:13882
747531
Macaque
polypeptide N-acetylgalactosaminyltransferase 12
715128
Mouse
MGI:2444664
230145
Rat
RGD:1562001
313233
Dog
polypeptide N-acetylgalactosaminyltransferase 12
VGNC:41087
474777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 12
Macaque
polypeptide N-acetylgalactosaminyltransferase 12
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IXK2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Defective GALNT12 causes colorectal cancer 1 (CRCS1) (R-HSA-5083636)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Protein-Protein Interactions (84)
1 – 10 of 84
PIANP
Tbio
Novelty: 0.01739512
p_int: 0.999722411
p_ni: 0.000277589
Data Source: BioPlex
BTC
Tbio
Novelty: 0.00673076
p_int: 0.999573339
p_ni: 0.000426661
Data Source: BioPlex
HPX
Tbio
Novelty: 0.00138137
p_int: 0.997271471
p_ni: 0.002728509
p_wrong: 1.9e-8
Score: 0.304
Data Source: BioPlex,STRINGDB
TMEM106A
Tbio
Novelty: 0.32470607
p_int: 0.995179969
p_ni: 0.004820031
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.988416274
p_ni: 0.011583721
p_wrong: 5e-9
Data Source: BioPlex
MGAT4C
Tdark
Family: Enzyme
Novelty: 0.19680806
p_int: 0.98800922
p_ni: 0.01199077
p_wrong: 1e-8
Data Source: BioPlex
GALNT7
Tbio
Family: Enzyme
Novelty: 0.05328171
p_int: 0.977625115
p_ni: 0.022374867
p_wrong: 1.8e-8
Score: 0.453
Data Source: BioPlex,STRINGDB
A2M
Tbio
Novelty: 0.00070446
p_int: 0.971645423
p_ni: 0.02835457
p_wrong: 7e-9
Data Source: BioPlex
PTPRA
Tchem
Family: Enzyme
Novelty: 0.01392344
p_int: 0.963251039
p_ni: 0.036748951
p_wrong: 1e-8
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.959936365
p_ni: 0.037296742
p_wrong: 0.002766892
Data Source: BioPlex
Publication Statistics
PubMed Score  12.66

PubMed score by year
PubTator Score  7.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer