You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PHC2
Polyhomeotic-like protein 2

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided b ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.8
virus perturbation
0.79
PubMedID
0.77
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
4
3
3
1
81.6
eosinophil count
2
2
2
78.7
smoking status measurement
3
2
2
1
71.6
blood urea nitrogen measurement
2
2
2
58.2
eosinophil percentage of leukocytes
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
3
1
81.6
eosinophil count
2
78.7
smoking status measurement
2
1
71.6
blood urea nitrogen measurement
2
58.2
eosinophil percentage of leukocytes
1
57.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polyhomeotic homolog 2
VGNC:6941
456729
Macaque
polyhomeotic homolog 2
710201
Mouse
MGI:1860454
54383
Rat
RGD:1307912
313038
Dog
polyhomeotic homolog 2
VGNC:44478
487297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polyhomeotic homolog 2
Macaque
polyhomeotic homolog 2
Mouse
Rat
Dog
polyhomeotic homolog 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IXK0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (176)
1 – 10 of 176
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.99999998
p_ni:  2e-8
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.9999998
p_ni:  2e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
CBX7
Tchem
Family:  Epigenetic
Novelty:  0.01612606
p_int:  0.999817324
p_ni:  0.000182674
p_wrong:  2e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
SFTPC
Tbio
Novelty:  0.00154396
p_int:  0.993378609
p_ni:  0.006621314
p_wrong:  7.7e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
RPL7
Tbio
Novelty:  0.00552644
p_int:  0.980739865
p_ni:  0.019260134
Score:  0.179
Data Source:  BioPlex,STRINGDB
BMI1
Tbio
Novelty:  0.00158043
Score:  0.996
Data Source:  STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.995
Data Source:  STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.992
Data Source:  STRINGDB
CBX4
Tchem
Family:  Epigenetic
Novelty:  0.02681197
Score:  0.987
Data Source:  STRINGDB
CBX8
Tchem
Family:  Epigenetic
Novelty:  0.00205993
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.52

PubMed score by year
PubTator Score  523.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: