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Tchem
SIRT2
NAD-dependent protein deacetylase sirtuin-2

Protein Summary
Description
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249396
  • ENSP00000249396
  • ENSG00000068903
  • ENST00000392081
  • ENSP00000375931
  • ENST00000634533
  • ENSP00000489602
  • ENSG00000283100
  • ENST00000635478
  • ENSP00000488940

Symbol
  • SIR2L
  • SIR2L2
  • SIR2
  • SIR2L
  • SIR2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease perturbation
0.96
hub protein
0.96
cellular component
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.46   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.46   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 194
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (194)
bisindolylmaleimide IX
Rendered image for bisindolylmaleimide IX
CHEMBL4438193
Rendered image for CHEMBL4438193
SRT1720
Rendered image for SRT1720
CHEMBL2332041
Rendered image for CHEMBL2332041
CHEMBL2332039
Rendered image for CHEMBL2332039
CHEMBL2332037
Rendered image for CHEMBL2332037
CHEMBL2338810
Rendered image for CHEMBL2338810
CHEMBL2332043
Rendered image for CHEMBL2332043
CHEMBL2332042
Rendered image for CHEMBL2332042
CHEMBL2332040
Rendered image for CHEMBL2332040
Protein-Protein Interactions (246)
SARS
Tbio
Family:  Enzyme
Novelty:  0.00963508
p_int:  0.999999962
p_ni:  3.8e-8
Score:  0.587
Data Source:  BioPlex,STRINGDB
SCFD2
Tdark
Novelty:  0.38252131
p_int:  0.999999853
p_ni:  1.47e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
RAB3GAP1
Tbio
Family:  Enzyme
Novelty:  0.0286836
p_int:  0.999999845
p_ni:  1.54e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
p_int:  0.999998495
p_ni:  0.000001238
p_wrong:  2.67e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
CST5
Tbio
Novelty:  0.04273227
p_int:  0.999988597
p_ni:  0.000011403
Data Source:  BioPlex
ORC2
Tbio
Novelty:  0.11963517
p_int:  0.999961248
p_ni:  0.000032321
p_wrong:  0.000006432
Score:  0.309
Data Source:  BioPlex,STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
p_int:  0.999918561
p_ni:  0.000081439
Score:  0.305
Data Source:  BioPlex,STRINGDB
MTDH
Tbio
Novelty:  0.00342872
p_int:  0.999343497
p_ni:  0.000656503
Score:  0.209
Data Source:  BioPlex,STRINGDB
MOAP1
Tbio
Novelty:  0.05070263
p_int:  0.997619713
p_ni:  0.002379814
p_wrong:  4.74e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
p_int:  0.997448879
p_ni:  0.002551104
p_wrong:  1.7e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (96)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
81.1
SIR2-like protein 2 measurement
1
1
1
81.1
serum gamma-glutamyl transferase measurement
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
50.6
diastolic blood pressure
1
1
1
40.7
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
81.1
SIR2-like protein 2 measurement
1
81.1
serum gamma-glutamyl transferase measurement
1
50.6
serum gamma-glutamyl transferase measurement
1
50.6
diastolic blood pressure
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 2
VGNC:12099
456013
Macaque
sirtuin 2
100425019
Mouse
MGI:1927664
64383
Rat
RGD:621481
361532
Dog
sirtuin 2
VGNC:53983
612558
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 2
Macaque
sirtuin 2
Mouse
Rat
Dog
sirtuin 2
Publication Statistics
PubMed Score 1193.46
PubMed score by year
PubTator Score 381.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title