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Tchem
SIRT2
NAD-dependent protein deacetylase sirtuin-2

Protein Summary
Description
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249396
  • ENSP00000249396
  • ENSG00000068903
  • ENST00000392081
  • ENSP00000375931
  • ENST00000634533
  • ENSP00000489602
  • ENSG00000283100
  • ENST00000635478
  • ENSP00000488940

Symbol
  • SIR2L
  • SIR2L2
  • SIR2
  • SIR2L
  • SIR2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease perturbation
0.96
hub protein
0.96
cellular component
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1360.88   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1360.88   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0