You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SIRT2
NAD-dependent protein deacetylase sirtuin-2

Protein Summary
Description
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249396
  • ENSP00000249396
  • ENSG00000068903
  • ENST00000392081
  • ENSP00000375931
  • ENST00000634533
  • ENSP00000489602
  • ENSG00000283100
  • ENST00000635478
  • ENSP00000488940

Symbol
  • SIR2L
  • SIR2L2
  • SIR2
  • SIR2L
  • SIR2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease perturbation
0.96
hub protein
0.96
cellular component
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1149.64   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1149.64   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (143)
1 – 10 of 143
CHEMBL6291,CHEMBL1591531
chemical structure image
CHEMBL3806268
chemical structure image
CHEMBL2338812
chemical structure image
CHEMBL2332053
chemical structure image
CHEMBL2338811
chemical structure image
CHEMBL3804834
chemical structure image
CHEMBL3805950
chemical structure image
CHEMBL3889954
chemical structure image
CHEMBL2338818
chemical structure image
CHEMBL3781645
chemical structure image
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
75.9
SIR2-like protein 2 measurement
1
1
1
75.9
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
75.9
SIR2-like protein 2 measurement
1
75.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 2
VGNC:12099
456013
Macaque
sirtuin 2
100425019
Mouse
MGI:1927664
64383
Rat
RGD:621481
361532
Dog
sirtuin 2
VGNC:53983
612558
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 2
Macaque
sirtuin 2
Mouse
Rat
Dog
sirtuin 2
Protein Structure (29 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IXJ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 29
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (96)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (246)
1 – 10 of 246
SARS
Tbio
Family: Enzyme
Novelty: 0.00963508
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.587
Data Source: BioPlex,STRINGDB
SCFD2
Tdark
Novelty: 0.38252131
p_int: 0.999999853
p_ni: 1.47e-7
Score: 0.207
Data Source: BioPlex,STRINGDB
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
p_int: 0.999999845
p_ni: 1.54e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
GPAM
Tbio
Family: Enzyme
Novelty: 0.00973127
p_int: 0.999998495
p_ni: 0.000001238
p_wrong: 2.67e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
CST5
Tbio
Novelty: 0.04273227
p_int: 0.999988597
p_ni: 0.000011403
Data Source: BioPlex
ORC2
Tbio
Novelty: 0.11963517
p_int: 0.999961248
p_ni: 0.000032321
p_wrong: 0.000006432
Score: 0.309
Data Source: BioPlex,STRINGDB
SNAI1
Tbio
Family: TF
Novelty: 0.00040495
p_int: 0.999918561
p_ni: 0.000081439
Score: 0.305
Data Source: BioPlex,STRINGDB
MTDH
Tbio
Novelty: 0.00342872
p_int: 0.999343497
p_ni: 0.000656503
Score: 0.209
Data Source: BioPlex,STRINGDB
MOAP1
Tbio
Novelty: 0.05070263
p_int: 0.997619713
p_ni: 0.002379814
p_wrong: 4.74e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
FADS1
Tchem
Family: Enzyme
Novelty: 0.00160193
p_int: 0.997448879
p_ni: 0.002551104
p_wrong: 1.7e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1149.64

PubMed score by year
PubTator Score  381.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: