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Tbio
RHOT2
Mitochondrial Rho GTPase 2

Protein Summary
Description
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315082
  • ENSP00000321971
  • ENSG00000140983

Symbol
  • ARHT2
  • C16orf39
  • RASL
  • ARHT2
  • MIRO2
  • MIRO-2
  • C16orf39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.95
molecular function
0.95
histone modification site profile
0.73
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.42   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.42   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
11
91.8
reticulocyte measurement
2
2
2
85.8
mean corpuscular volume
1
1
1
84
BMI-adjusted waist circumference
1
7
7
82.8
mean reticulocyte volume
1
2
2
81.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
91.8
reticulocyte measurement
2
85.8
mean corpuscular volume
1
84
BMI-adjusted waist circumference
7
82.8
mean reticulocyte volume
2
81.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member T2
VGNC:9010
453800
Macaque
ras homolog family member T2
722352
Mouse
MGI:2384892
214952
Rat
RGD:727970
287156
Dog
ras homolog family member T2
VGNC:45564
479893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member T2
Macaque
ras homolog family member T2
Mouse
Rat
Dog
ras homolog family member T2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IXI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (217)
1 – 10 of 217
UBC
Tbio
Novelty:  0.00204643
p_int:  1
Score:  0.419
Data Source:  BioPlex,STRINGDB
MRPL20
Tdark
Novelty:  0.91178993
p_int:  0.998412699
p_ni:  0.001587301
Score:  0.181
Data Source:  BioPlex,STRINGDB
RHOT1
Tbio
Family:  Enzyme
Novelty:  0.01411527
p_int:  0.998011044
p_ni:  0.001988956
Score:  0.919
Data Source:  BioPlex,STRINGDB
SARM1
Tchem
Novelty:  0.00510488
p_int:  0.996473913
p_ni:  0.003525779
p_wrong:  3.08e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
XPR1
Tbio
Novelty:  0.00735578
p_int:  0.974953217
p_ni:  0.025046783
Score:  0.161
Data Source:  BioPlex,STRINGDB
FKRP
Tbio
Novelty:  0.00798137
p_int:  0.970518837
p_ni:  0.029481163
Score:  0.183
Data Source:  BioPlex,STRINGDB
WDFY3
Tbio
Novelty:  0.01670166
p_int:  0.965687524
p_ni:  0.034312476
Score:  0.246
Data Source:  BioPlex,STRINGDB
MYO19
Tbio
Novelty:  0.13070371
p_int:  0.901594276
p_ni:  0.098405724
Score:  0.645
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.81192603
p_ni:  0.18807397
Score:  0.162
Data Source:  BioPlex,STRINGDB
BTAF1
Tbio
Novelty:  0.01586704
p_int:  0.80460832
p_ni:  0.19539168
Score:  0.181
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.42

PubMed score by year
PubTator Score  19.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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