Tbio NELFCD Negative elongation factor C/D

Protein Summary

Description

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner. The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IXH7
• B4DE06
• Q9BYL2
• Q9H405
• Q9H888
• Q9H8T3
• Q9NVX5
• Q9P029
• Q9UGN1
• Q9UGN2
• Q9UGN3
• NELF-C/D

Gene Name

• NELFCD

Ensembl ID

• ENST00000344018
• ENSP00000342300
• ENSG00000101158

Symbol

• NELFD
• TH1
• TH1L
• TH1
• TH1L
• NELF-C
• NELF-D
• HSPC130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
kinase perturbation	0.71
biological process	0.68
cell type or tissue	0.68
pathway	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1010.12   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1010.12   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0