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Tbio
NELFCD
Negative elongation factor C/D

Protein Summary
Description
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner. The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
kinase perturbation
0.71
biological process
0.68
cell type or tissue
0.68
pathway
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.4   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.4   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
10
13
99.6
platelet count
6
8
9
18.6
98.6
platelet crit
1
2
2
95.9
reticulocyte count
2
1
2
78.3
blood urea nitrogen measurement
3
3
3
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
13
99.6
platelet count
9
18.6
98.6
platelet crit
2
95.9
reticulocyte count
2
78.3
blood urea nitrogen measurement
3
73.8
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926424
57314
Pig
negative elongation factor complex member C/D
100134985
Zebrafish
ZDB-GENE-040426-720
394165
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Pig
negative elongation factor complex member C/D
Zebrafish
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IXH7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (150)
1 – 10 of 150
NELFE
Tbio
Novelty:  0.02136256
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.999999984
p_ni:  1.3e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.999990523
p_ni:  0.000009476
p_wrong:  1e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
NELFB
Tbio
Novelty:  0.05821821
Score:  0.994
Data Source:  Reactome,STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.985
Data Source:  Reactome,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.984
Data Source:  Reactome,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.982
Data Source:  Reactome,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.918
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.918
Data Source:  STRINGDB
CDC73
Tbio
Novelty:  0.00362973
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  895.40

PubMed score by year
PubTator Score  5955.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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