Tbio TP53INP2 Tumor protein p53-inducible nuclear protein 2

Protein Summary

Description

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q8IXH6
• A8K8S8
• E1P5P6
• Q5JX64
• Q8IYL5
• Q9NU00

Gene Name

• TP53INP2

Ensembl ID

• ENST00000374809
• ENSP00000363942
• ENSG00000078804
• ENST00000374810
• ENSP00000363943

Symbol

• C20orf110
• DOR
• PINH
• DOR
• PIGU
• PINH
• PIG-U
• C20orf110
• dJ1181N3.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.79
microRNA	0.75
transcription factor binding site profile	0.75
small molecule perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.79   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.79   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0