Tbio DNAJC10 DnaJ homolog subfamily C member 10

Protein Summary

Description

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q8IXB1
• Q17RJ6
• Q3B7W8
• Q4ZG06
• Q53QT7
• Q6UWZ6
• Q86T61
• Q8NC82
• Q8TD87
• Q96K38
• Q96K44
• Q96K54
• Q9NSY6

Gene Name

• DNAJC10

Ensembl ID

• ENST00000264065
• ENSP00000264065
• ENSG00000077232
• ENST00000537515
• ENSP00000441560
• ENST00000616986
• ENSP00000479930

Symbol

• ERDJ5
• JPDI
• MTHr
• ERdj5
• PDIA19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
interacting protein	0.96
histone modification site profile	0.92
kinase perturbation	0.81
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.12   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.12   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0