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Tbio
SLF2
SMC5-SMC6 complex localization factor protein 2

Protein Summary
Description
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238961
  • ENSP00000238961
  • ENSG00000119906
  • ENST00000370269
  • ENSP00000359292
  • ENST00000609386
  • ENSP00000476379

Symbol
  • C10orf6
  • FAM178A
  • C10orf6
  • FAM178A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.44   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.44   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (34)
1 – 10 of 34
NSMCE1
Tdark
Novelty: 6
p_int: 0.99999096
p_ni: 1.69e-7
p_wrong: 0.000008871
Score: 0.527
Data Source: BioPlex,STRINGDB
SLF1
Tbio
Novelty: 0.12145749
Score: 0.961
Data Source: STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00575302
Score: 0.921
Data Source: STRINGDB
TWNK
Tbio
Novelty: 0.00568711
Score: 0.749
Data Source: STRINGDB
SMC6
Tbio
Novelty: 0.03375388
Score: 0.733
Data Source: STRINGDB
TESK2
Tchem
Family: Kinase
Novelty: 0.49763033
Score: 0.713
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00014684
Score: 0.703
Data Source: STRINGDB
DALRD3
Tdark
Novelty: 3.23076923
Score: 0.695
Data Source: STRINGDB
NSMCE3
Tbio
Novelty: 0.00337667
Score: 0.656
Data Source: STRINGDB
PEX1
Tbio
Family: Enzyme
Novelty: 0.09189032
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.44

PubMed score by year
PubTator Score  2.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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