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Tdark
MCEMP1
Mast cell-expressed membrane protein 1

Protein Summary
Description
This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333598
  • ENSP00000329920
  • ENSG00000183019

Symbol
  • C19orf59
  • C19orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
tissue sample
0.41
protein complex
0.4
tissue
0.4
transcription factor
0.33


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
5
95.6
resistin measurement
1
2
0
6.2
91.1
leukocyte count
1
3
3
89.1
aspartate aminotransferase measurement
1
1
0
9.5
73.9
von Willebrand factor measurement
1
1
2
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
95.6
resistin measurement
0
6.2
91.1
leukocyte count
3
89.1
aspartate aminotransferase measurement
0
9.5
73.9
von Willebrand factor measurement
2
65.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mast cell expressed membrane protein 1
VGNC:14747
100174911
Macaque
mast cell expressed membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:27291]
Mouse
MGI:1916439
69189
Rat
RGD:1565374
498128
Dog
mast cell expressed membrane protein 1
611542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mast cell expressed membrane protein 1
Macaque
mast cell expressed membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:27291]
Mouse
Rat
Dog
mast cell expressed membrane protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IX19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (147)
1 – 10 of 147
JOSD2
Tbio
Novelty:  0.27109362
p_int:  0.995608763
p_ni:  0.004391237
Score:  0.513
Data Source:  BioPlex,STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.946
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.944
Data Source:  STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.936
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.935
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.933
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.932
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.931
Data Source:  STRINGDB
RAB44
Tdark
Family:  Enzyme
Novelty:  0.16987153
Score:  0.93
Data Source:  STRINGDB
P2RX1
Tchem
Family:  IC
Novelty:  0.00286826
Score:  0.93
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.85

PubMed score by year
PubTator Score  4.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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