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Tdark
DHX40
Probable ATP-dependent RNA helicase DHX40

Protein Summary
Description
Probable ATP-dependent RNA helicase. This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251241
  • ENSP00000251241
  • ENSG00000108406
  • ENST00000425628
  • ENSP00000388749

Symbol
  • DDX40
  • PAD
  • DDX40
  • ARG147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
protein domain
0.92
histone modification site profile
0.91
transcription factor
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
PPIL4
Tdark
Family: Enzyme
Novelty: 0.3737992
p_int: 0.999999892
p_ni: 1.08e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
HERC1
Tbio
Family: Enzyme
Novelty: 0.04318441
p_int: 0.999806434
p_ni: 0.000193566
Data Source: BioPlex
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
p_int: 0.999582913
p_ni: 0.000417087
Score: 0.173
Data Source: BioPlex,STRINGDB
TRIM27
Tbio
Novelty: 0.02102013
p_int: 0.999370468
p_ni: 0.000629529
p_wrong: 3e-9
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999326095
p_ni: 0.000673905
Data Source: BioPlex
NUDCD1
Tbio
Novelty: 0.07471096
p_int: 0.996849193
p_ni: 0.003150807
Data Source: BioPlex
ECE2
Tchem
Family: Enzyme
Novelty: 0.03234301
p_int: 0.99246903
p_ni: 0.00753097
Score: 0.394
Data Source: BioPlex,STRINGDB
EPM2AIP1
Tdark
Novelty: 0.1803524
p_int: 0.992373489
p_ni: 0.007626511
Score: 0.54
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.932195505
p_ni: 0.067804494
p_wrong: 1e-9
Data Source: BioPlex
ATXN7L1
Tdark
Novelty: 0.43694835
p_int: 0.901514144
p_ni: 0.098485711
p_wrong: 1.44e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  2.93

PubMed score by year
PubTator Score  12.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer