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Tdark
UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

Protein Summary
Description
Possible negative regulator of polyubiquitination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300038
  • ENSP00000300038
  • ENSG00000151116
  • ENST00000320750
  • ENSP00000323353
  • ENST00000379387
  • ENSP00000368697
  • ENST00000396197
  • ENSP00000379500
  • ENST00000535484
  • ENSP00000441092
  • ENST00000541984
  • ENSP00000437538
  • ENST00000543987
  • ENSP00000442974

Symbol
  • UEV3
  • ATTP
  • UEV3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.84
kinase perturbation
0.66
virus perturbation
0.64
transcription factor perturbation
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UEV and lactate/malate dehyrogenase domains
VGNC:6545
748881
Macaque
UEV and lactate/malate dehyrogenase domains
693656
Mouse
MGI:1860490
54122
Rat
RGD:1587416
691172
Dog
UEV and lactate/malate dehyrogenase domains
VGNC:48112
612008
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UEV and lactate/malate dehyrogenase domains
Macaque
UEV and lactate/malate dehyrogenase domains
Mouse
Rat
Dog
UEV and lactate/malate dehyrogenase domains
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IX04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (85)
1 – 10 of 85
MORN4
Tdark
Novelty: 0.22826325
p_int: 0.99999981
p_ni: 1e-9
p_wrong: 1.9e-7
Data Source: BioPlex
WDR59
Tdark
Novelty: 0.22243351
p_int: 0.999936849
p_ni: 3.25e-7
p_wrong: 0.000062826
Score: 0.332
Data Source: BioPlex,STRINGDB
VPS28
Tbio
Novelty: 0.02927315
Score: 0.866
Data Source: STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.803
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.743
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.717
Data Source: STRINGDB
VPS36
Tbio
Novelty: 0.03382542
Score: 0.696
Data Source: STRINGDB
DNAJC30
Tdark
Novelty: 0.57178901
Score: 0.658
Data Source: STRINGDB
SNF8
Tbio
Novelty: 0.04841708
Score: 0.616
Data Source: STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
Score: 0.615
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.16

PubMed score by year
PubTator Score  73.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer