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Tdark
TRIM48
Tripartite motif-containing protein 48

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417545
  • ENSP00000402414
  • ENSG00000150244

Symbol
  • RNF101
  • RNF101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
microRNA
0.71
cell line
0.6
gene perturbation
0.49
protein domain
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
37.5
intraocular pressure measurement
1
1
1
21.2
lymphocyte count
1
1
1
20.9
C-reactive protein measurement
1
1
1
15.6
mean platelet volume
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
37.5
intraocular pressure measurement
1
21.2
lymphocyte count
1
20.9
C-reactive protein measurement
1
15.6
mean platelet volume
1
13.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IWZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (149)
1 – 10 of 149
PML
Tbio
Novelty:  0.00285474
Score:  0.912
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.909
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.904
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.902
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.902
Data Source:  STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.901
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.9
Data Source:  STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.9
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.9
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.61

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer