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Tbio
ANKHD1
Ankyrin repeat and KH domain-containing protein 1

Protein Summary
Description
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360839
  • ENSP00000354085
  • ENSG00000131503
  • ENST00000394722
  • ENSP00000378211
  • ENST00000394723
  • ENSP00000378212
  • ENST00000616482
  • ENSP00000478529

Symbol
  • KIAA1085
  • MASK
  • VBARP
  • MASK-BP3
  • MASK-BP3ARF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.86
interacting protein
0.83
histone modification site profile
0.8
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (77)
1 – 10 of 77
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.999998298
p_ni: 0.000001702
Data Source: BioPlex
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
p_int: 0.999997147
p_ni: 0.000002853
Data Source: BioPlex
FGF17
Tbio
Novelty: 0.01432991
p_int: 0.999960077
p_ni: 0.000039923
Data Source: BioPlex
TCEANC2
Tdark
Novelty: 0.40325323
p_int: 0.999929746
p_ni: 0.000070254
Data Source: BioPlex
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999914349
p_ni: 0.000085652
Data Source: BioPlex
TGIF2LY
Tdark
Family: TF
p_int: 0.999876528
p_ni: 0.000123471
p_wrong: 1e-9
Data Source: BioPlex
HOXC4
Tbio
Family: TF
Novelty: 0.02206351
p_int: 0.999807369
p_ni: 0.000192631
Score: 0.219
Data Source: BioPlex,STRINGDB
HOXB6
Tbio
Family: TF
Novelty: 0.0176813
p_int: 0.999684127
p_ni: 0.000315873
Data Source: BioPlex
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.999565341
p_ni: 0.000434659
Score: 0.196
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999508075
p_ni: 0.000491926
Data Source: BioPlex
Publication Statistics
PubMed Score  23.47

PubMed score by year
PubTator Score  2.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer