ANKHD1
Ankyrin repeat and KH domain-containing protein 1
Protein Summary
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
- ENST00000360839
- ENSP00000354085
- ENSG00000131503
- ENST00000394722
- ENSP00000378211
- ENST00000394723
- ENSP00000378212
- ENST00000616482
- ENSP00000478529
- KIAA1085
- MASK
- VBARP
- MASK-BP3
- MASK-BP3ARF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.86 | ||
interacting protein | 0.83 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.29 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.29 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
HPSE2
Family: Enzyme
Novelty: 0.00583615
p_int: 0.999997147
p_ni: 0.000002853
Data Source: BioPlex
HOXC4
Family: TF
Novelty: 0.02206351
p_int: 0.999807369
p_ni: 0.000192631
Score: 0.219
Data Source: BioPlex,STRINGDB
ZNF414
Novelty: 1.29024829
p_int: 0.999565341
p_ni: 0.000434659
Score: 0.196
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 3 | 5 | 2 | 5.9 | 57.7 | ||||
white matter integrity | 2 | 1 | 2 | 35 | |||||
creatine kinase measurement | 1 | 1 | 1 | 31.4 | |||||
monocyte count | 1 | 1 | 1 | 13.8 | |||||
inflammatory biomarker measurement | 1 | 1 | 0 | 125.7 | 6.1 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 2 | 5.9 | 57.7 | ||||
white matter integrity | 2 | 35 | |||||
creatine kinase measurement | 1 | 31.4 | |||||
monocyte count | 1 | 13.8 | |||||
inflammatory biomarker measurement | 0 | 125.7 | 6.1 | ||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 24.29
PubMed score by year
PubTator Score 2.33
PubTator score by year
Related Publications
Text Mined References (8)
Items per page:
0 of 0
PMID | Year | Title |
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