Tbio CDAN1 Codanin-1

Protein Summary

Description

May act as a negative regulator of ASF1 in chromatin assembly. This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q8IWY9
• Q6NYD0
• Q7Z7L5
• Q969N3

Gene Name

• CDAN1

Ensembl ID

• ENST00000356231
• ENSP00000348564
• ENSG00000140326

Symbol

• DLT
• CDA1
• CDAI
• CDAN1A
• PRO1295

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
histone modification site profile	0.73
tissue	0.56
tissue sample	0.56
cell type or tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.41   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.41   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0