Tbio ADHFE1 Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Protein Summary

Description

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8IWW8
• B4DTJ8
• Q49A19
• Q68CI7
• Q6P2B6
• Q96MF9
• HOT

Gene Name

• ADHFE1

Ensembl ID

• ENST00000396623
• ENSP00000379865
• ENSG00000147576
• ENST00000415254
• ENSP00000407115
• ENST00000424777
• ENSP00000410883

Symbol

• HOT
• ADH8
• HMFT2263

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.87
gene perturbation	0.65
pathway	0.65
virus perturbation	0.64
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0