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Tbio
ADHFE1
Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Protein Summary
Description
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396623
  • ENSP00000379865
  • ENSG00000147576
  • ENST00000415254
  • ENSP00000407115
  • ENST00000424777
  • ENSP00000410883

Symbol
  • HOT
  • ADH8
  • HMFT2263
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.87
gene perturbation
0.65
pathway
0.65
virus perturbation
0.64
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
ADH5
Tchem
Family:  Enzyme
Novelty:  0.00248968
Score:  0.92
Data Source:  STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.886
Data Source:  STRINGDB
ALDH8A1
Tbio
Family:  Enzyme
Novelty:  0.09598756
Score:  0.763
Data Source:  STRINGDB
ADH7
Tchem
Family:  Enzyme
Novelty:  0.00488034
Score:  0.754
Data Source:  STRINGDB
ADH4
Tbio
Family:  Enzyme
Novelty:  0.00358463
Score:  0.73
Data Source:  STRINGDB
ADH6
Tbio
Family:  Enzyme
Novelty:  0.01102438
Score:  0.725
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.723
Data Source:  STRINGDB
ADH1A
Tclin
Family:  Enzyme
Novelty:  0.00199598
Score:  0.7
Data Source:  STRINGDB
ECHDC1
Tbio
Family:  Enzyme
Novelty:  0.02711265
Score:  0.686
Data Source:  STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
Score:  0.679
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (R-HSA-880009)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
66.3
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alcohol dehydrogenase, iron containing 1
703118
Mouse
MGI:1923437
76187
Rat
RGD:1308863
362474
Dog
alcohol dehydrogenase, iron containing 1
VGNC:37655
477899
Horse
alcohol dehydrogenase, iron containing 1
VGNC:15117
100063782
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alcohol dehydrogenase, iron containing 1
Mouse
Rat
Dog
alcohol dehydrogenase, iron containing 1
Horse
alcohol dehydrogenase, iron containing 1
Publication Statistics
PubMed Score 28.24
PubMed score by year
PubTator Score 197.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title