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Tbio
ARHGAP12
Rho GTPase-activating protein 12

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311380
  • ENSP00000310984
  • ENSG00000165322
  • ENST00000344936
  • ENSP00000345808
  • ENST00000375250
  • ENSP00000364399
  • ENST00000396144
  • ENSP00000379448
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
cell type or tissue
0.92
protein domain
0.92
transcription factor binding site profile
0.91
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ASAP1
Tbio
Novelty:  0.00913771
p_int:  0.999999966
p_ni:  3.4e-8
Data Source:  BioPlex
SHANK3
Tbio
p_int:  0.999999946
p_ni:  5e-9
p_wrong:  4.8e-8
Data Source:  BioPlex
ASAP2
Tbio
Novelty:  0.02744569
p_int:  0.999999867
p_ni:  1.33e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
TJP2
Tbio
Novelty:  0.00446681
p_int:  0.999999482
p_ni:  5.18e-7
Data Source:  BioPlex
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999976109
p_ni:  0.000023887
p_wrong:  3e-9
Data Source:  BioPlex
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999966676
p_ni:  0.000033324
Data Source:  BioPlex
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999938001
p_ni:  0.000061999
Data Source:  BioPlex
RAPH1
Tbio
Novelty:  0.02440794
p_int:  0.99992327
p_ni:  0.000075964
p_wrong:  7.66e-7
Data Source:  BioPlex
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.999912443
p_ni:  0.00008687
p_wrong:  6.87e-7
Score:  0.325
Data Source:  BioPlex,STRINGDB
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.999748334
p_ni:  0.000251666
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
9.2
low density lipoprotein cholesterol measurement
1
1
1
7.5
glycine measurement
1
1
1
5
1
1
0
5.6
4.8
age at onset
1
1
0
5.6
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
9.2
low density lipoprotein cholesterol measurement
1
7.5
glycine measurement
1
5
0
5.6
4.8
age at onset
0
5.6
4.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 12
VGNC:3807
450389
Macaque
Rho GTPase activating protein 12
696402
Mouse
MGI:1922665
75415
Rat
RGD:1310017
307016
Dog
Rho GTPase activating protein 12
VGNC:38046
487088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 12
Macaque
Rho GTPase activating protein 12
Mouse
Rat
Dog
Rho GTPase activating protein 12
Publication Statistics
PubMed Score 8.52
PubMed score by year
PubTator Score 5.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title