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Tbio
UBR2
E3 ubiquitin-protein ligase UBR2

Protein Summary
Description
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (By similarity). This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372899
  • ENSP00000361990
  • ENSG00000024048
  • ENST00000372901
  • ENSP00000361992
  • ENST00000372903
  • ENSP00000361994

Symbol
  • C6orf133
  • KIAA0349
  • C6orf133
  • bA49A4.1
  • dJ242G1.1
  • dJ392M17.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.9
transcription factor perturbation
0.88
biological process
0.83
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
91.3
eosinophil percentage of leukocytes
2
2
2
76.1
neutrophil percentage of leukocytes
2
2
2
76.1
body mass index
1
1
1
46.5
monocyte percentage of leukocytes
2
1
2
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
91.3
eosinophil percentage of leukocytes
2
76.1
neutrophil percentage of leukocytes
2
76.1
body mass index
1
46.5
monocyte percentage of leukocytes
2
28.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 2
VGNC:12739
462696
Macaque
ubiquitin protein ligase E3 component n-recognin 2
696507
Mouse
MGI:1861099
224826
Rat
RGD:1593237
363188
Dog
ubiquitin protein ligase E3 component n-recognin 2
VGNC:48090
474903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 2
Macaque
ubiquitin protein ligase E3 component n-recognin 2
Mouse
Rat
Dog
ubiquitin protein ligase E3 component n-recognin 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWV8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (336)
1 – 10 of 336
PLEKHO2
Tdark
Novelty:  0.48296621
p_int:  0.999998241
p_ni:  0.000001759
Data Source:  BioPlex
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.999983265
p_ni:  0.000016735
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.997933351
p_ni:  0.002066649
Data Source:  BioPlex
NUDT16
Tbio
Novelty:  0.06032864
p_int:  0.99622136
p_ni:  0.00377864
Data Source:  BioPlex
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.99315068
p_ni:  0.00684932
Data Source:  BioPlex
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.991720755
p_ni:  0.008279245
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.991238909
p_ni:  0.008761086
p_wrong:  4e-9
Data Source:  BioPlex
HS3ST2
Tbio
Family:  Enzyme
Novelty:  0.0611326
p_int:  0.99111927
p_ni:  0.00888073
Data Source:  BioPlex
SOD2
Tbio
Family:  Enzyme
Novelty:  0.00084288
p_int:  0.986386644
p_ni:  0.013613356
Score:  0.537
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.985310644
p_ni:  0.014689356
Data Source:  BioPlex
Publication Statistics
PubMed Score  32.16

PubMed score by year
PubTator Score  9.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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