You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CNTN4
Contactin-4

Protein Summary
Description
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis. This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397459
  • ENSP00000380600
  • ENSG00000144619
  • ENST00000397461
  • ENSP00000380602
  • ENST00000418658
  • ENSP00000396010
  • ENST00000427331
  • ENSP00000413642

Symbol
  • AXCAM
  • BIG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.85
cell type or tissue
0.74
disease
0.74
phenotype
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.79   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.79   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.927
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.927
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.923
Data Source:  STRINGDB
MELTF
Tbio
Novelty:  0.00853228
Score:  0.921
Data Source:  STRINGDB
LSAMP
Tbio
Novelty:  0.01237032
Score:  0.92
Data Source:  STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
Score:  0.917
Data Source:  STRINGDB
MDGA2
Tbio
Novelty:  0.07784646
Score:  0.916
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.915
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.912
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
7
98
eosinophil percentage of leukocytes
2
7
7
97.5
basophil percentage of leukocytes
2
5
6
92.4
basophil count
3
4
6
89.7
basophil percentage of granulocytes
1
2
2
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
98
eosinophil percentage of leukocytes
7
97.5
basophil percentage of leukocytes
6
92.4
basophil count
6
89.7
basophil percentage of granulocytes
2
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
contactin 4
VGNC:1785
470734
Macaque
contactin 4
704763
Mouse
MGI:1095737
269784
Rat
RGD:621361
116658
Dog
contactin 4
VGNC:39435
100686094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
contactin 4
Macaque
contactin 4
Mouse
Rat
Dog
contactin 4
Publication Statistics
PubMed Score 43.79
PubMed score by year
PubTator Score 48.54
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title