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Tchem
TPH2
Tryptophan 5-hydroxylase 2

Protein Summary
Description
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333850
  • ENSP00000329093
  • ENSG00000139287

Symbol
  • NTPH
  • NTPH
  • ADHD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.85
disease
0.68
phenotype
0.67
biological term
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.29   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.29   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tryptophan hydroxylase 2
664730
Mouse
MGI:2651811
216343
Rat
RGD:631332
317675
Dog
tryptophan hydroxylase 2
VGNC:47739
481165
Horse
tryptophan hydroxylase 2
VGNC:24431
100009684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tryptophan hydroxylase 2
Mouse
Rat
Dog
tryptophan hydroxylase 2
Horse
tryptophan hydroxylase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IWU9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Serotonin and melatonin biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Serotonin and melatonin biosynthesis
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
TPH1
Tclin
Family: Enzyme
Novelty: 0.00098637
p_int: 0.999999956
p_ni: 1e-9
p_wrong: 4.3e-8
Score: 0.814
Data Source: BioPlex,STRINGDB
EIF2A
Tbio
Novelty: 0.08652858
p_int: 0.999854398
p_ni: 0.000144837
p_wrong: 7.65e-7
Data Source: BioPlex
BLOC1S3
Tbio
Novelty: 0.08465735
p_int: 0.999807624
p_ni: 0.000018279
p_wrong: 0.000174098
Data Source: BioPlex
BLOC1S4
Tdark
Novelty: 1.06874265
p_int: 0.998777068
p_ni: 0.001209702
p_wrong: 0.00001323
Data Source: BioPlex
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.997770269
p_ni: 0.00222857
p_wrong: 0.000001162
Score: 0.388
Data Source: BioPlex,STRINGDB
SAMD1
Tdark
Novelty: 0.21956379
p_int: 0.933418369
p_ni: 0.066475943
p_wrong: 0.000105687
Data Source: BioPlex
SYBU
Tbio
Novelty: 0.06029092
p_int: 0.842022509
p_ni: 0.000909616
p_wrong: 0.157067875
Score: 0.297
Data Source: BioPlex,STRINGDB
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.822513596
p_ni: 0.061246371
p_wrong: 0.116240033
Data Source: BioPlex
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.969
Data Source: STRINGDB
QDPR
Tchem
Family: Enzyme
Novelty: 0.00836889
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  419.29

PubMed score by year
PubTator Score  285.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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