Tchem TPH2 Tryptophan 5-hydroxylase 2

Protein Summary

Description

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q8IWU9
• A6NGA4
• Q14CB0

Gene Name

• TPH2

Ensembl ID

• ENST00000333850
• ENSP00000329093
• ENSG00000139287

Symbol

• NTPH
• NTPH
• ADHD7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
protein domain	0.85
disease	0.68
phenotype	0.67
biological term	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.87   (req: < 5)

Gene RIFs: 244   (req: <= 3)

Antibodies: 501   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.87   (req: >= 5)

Gene RIFs: 244   (req: > 3)

Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0