TPH2
Tryptophan 5-hydroxylase 2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 1 | ||
protein domain | 0.85 | ||
disease | 0.68 | ||
phenotype | 0.67 | ||
biological term | 0.66 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Serotonin and melatonin biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Serotonin and melatonin biosynthesis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neuroticism measurement | 1 | 1 | 1 | 42.3 | |||||
wellbeing measurement | 1 | 1 | 1 | 42.3 | |||||
depressive symptom measurement | 1 | 1 | 1 | 42.3 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neuroticism measurement | 1 | 42.3 | |||||
wellbeing measurement | 1 | 42.3 | |||||
depressive symptom measurement | 1 | 42.3 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | tryptophan hydroxylase 2 | 664730 | ||||||
Mouse | MGI:2651811 | 216343 | ||||||
Rat | RGD:631332 | 317675 | ||||||
Dog | tryptophan hydroxylase 2 | VGNC:47739 | 481165 | |||||
Horse | tryptophan hydroxylase 2 | VGNC:24431 | 100009684 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | tryptophan hydroxylase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tryptophan hydroxylase 2 | |||||
Horse | tryptophan hydroxylase 2 | |||||
PMID | Year | Title |
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