TPH2
Tryptophan 5-hydroxylase 2
Protein Summary
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
- ENST00000333850
- ENSP00000329093
- ENSG00000139287
- NTPH
- NTPH
- ADHD7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
protein domain | 0.85 | ||
disease | 0.68 | ||
phenotype | 0.67 | ||
biological term | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 425.12 (req: < 5)
Gene RIFs: 217 (req: <= 3)
Antibodies: 501 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 425.12 (req: >= 5)
Gene RIFs: 217 (req: > 3)
Antibodies: 501 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (74)
TPH1
Family: Enzyme
Novelty: 0.00098637
p_int: 0.999999956
p_ni: 1e-9
p_wrong: 4.3e-8
Score: 0.814
Data Source: BioPlex,STRINGDB
EIF2A
Novelty: 0.08652858
p_int: 0.999854398
p_ni: 0.000144837
p_wrong: 7.65e-7
Data Source: BioPlex
BLOC1S3
Novelty: 0.08465735
p_int: 0.999807624
p_ni: 0.000018279
p_wrong: 0.000174098
Data Source: BioPlex
BLOC1S4
Novelty: 1.06874265
p_int: 0.998777068
p_ni: 0.001209702
p_wrong: 0.00001323
Data Source: BioPlex
DNAJC12
Novelty: 0.05214775
p_int: 0.997770269
p_ni: 0.00222857
p_wrong: 0.000001162
Score: 0.388
Data Source: BioPlex,STRINGDB
SAMD1
Novelty: 0.21956379
p_int: 0.933418369
p_ni: 0.066475943
p_wrong: 0.000105687
Data Source: BioPlex
SYBU
Novelty: 0.06029092
p_int: 0.842022509
p_ni: 0.000909616
p_wrong: 0.157067875
Score: 0.297
Data Source: BioPlex,STRINGDB
DTNBP1
Novelty: 0.00341619
p_int: 0.822513596
p_ni: 0.061246371
p_wrong: 0.116240033
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (23)
Reactome (4)
KEGG (4)
PathwayCommons (2)
UniProt (1)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Serotonin and melatonin biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Serotonin and melatonin biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (2)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neuroticism measurement | 1 | 1 | 1 | 42.3 | |||||
wellbeing measurement | 1 | 1 | 1 | 42.3 | |||||
depressive symptom measurement | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neuroticism measurement | 1 | 42.3 | |||||
wellbeing measurement | 1 | 42.3 | |||||
depressive symptom measurement | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | tryptophan hydroxylase 2 | 664730 | ||||||
Mouse | MGI:2651811 | 216343 | ||||||
Rat | RGD:631332 | 317675 | ||||||
Dog | tryptophan hydroxylase 2 | VGNC:47739 | 481165 | |||||
Horse | tryptophan hydroxylase 2 | VGNC:24431 | 100009684 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | tryptophan hydroxylase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tryptophan hydroxylase 2 | |||||
Horse | tryptophan hydroxylase 2 | |||||
Publication Statistics
PubMed Score 425.12
PubMed score by year
PubTator Score 285.50
PubTator score by year
Related Publications
Text Mined References (262)
GeneRif Annotations (217)
Items per page:
0 of 0
PMID | Year | Title |
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